Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts' studies

Didier Debieuvre; Olivier Molinier; Lionel Falchero; Chrystèle Locher; Dorine Templement-Grangerat; Nicolas Meyer; Hugues Morel; Yannick Duval; Bernard Asselain; Alexia Letierce; Jean Trédaniel; Jean-Bernard Auliac; Olivier Bylicki; Lionel Moreau; Mathieu Fore; Romain Corre; Sébastien Couraud; Alexis Cortot; Study Group KBP-2020-CPHG; KBP-2020-CPHG

doi:10.1016/j.lanepe.2022.100492

Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts' studies

Lancet Reg Health Eur. 2022 Aug 29:22:100492. doi: 10.1016/j.lanepe.2022.100492. eCollection 2022 Nov.

Authors

Didier Debieuvre¹, Olivier Molinier², Lionel Falchero³, Chrystèle Locher⁴, Dorine Templement-Grangerat⁵, Nicolas Meyer⁶, Hugues Morel⁷, Yannick Duval⁸, Bernard Asselain⁹, Alexia Letierce¹⁰, Jean Trédaniel¹¹, Jean-Bernard Auliac¹², Olivier Bylicki¹³, Lionel Moreau¹⁴, Mathieu Fore¹, Romain Corre¹⁵, Sébastien Couraud¹⁶, Alexis Cortot¹⁷; Study Group KBP-2020-CPHG; KBP-2020-CPHG

Collaborators

Faraj Al Freijat, Waad Al Sheikh, Claire Alizon, Karim Amrane, Jean-Bernard Auliac, Etienne Auvray, Nicolae Banciu, Alexandra Bedossa, Issam Belhaj, Antoine Belle, Laure Belmont, Kheir Eddine Benmammar, Marie Bernardi, Pascal Beynel, Fréderic Bigot, Acya Bizieux-Thaminy, Anne-Sophie Blanchet-Legens, Philippe Bonnefoy, Soraya Bordier, Anne-Sophie Bravard, Éric Briens, Philippe Brun, Anne-Sophie Bugnet, Olivier Bylicki, Laetitia Chablais, Anne-Marie Chiappa, Reda Chikouche, François Christiann, Caroline Clarot, Romain Corre, Joelle Courdeau-Labourie, Jacky Crequit, Charles Dayen, Gonzague De Chabot, Didier Debieuvre, Chantal Decroisette, Stéphanie Dehette, Christian Delafosse, Bertrand Delclaux, Christina Delmas, Pierre Demontrond, Jean-Marc Dot, Cécile Dujon, Patrick Dumont, Christine Dussopt, Fatima Duval, Fethi El Khanjari, Lionel Falchero, Kevin Fouet, Hugues Francois, Yannick Ghalloussi-Tebai, Éric Goarant, Benoît Godbert, François Goupil, Rym Haouachi, Pierre-Alexandre Hauss, Mohamad Jaafar, Baihas Jarjour, Serge Jeandeau, Sylvie Julien, Jean Philippe Kraemer, Pierre Kuntz, Florence Lamotte, Sébastien Larive, Thomas Laurent, Hervé Le Floch, Gwenaëlle Le Garff, Jacques Le Treut, Emmanuelle Lecuyer, Christine Lefoll, Olivier Leleu, Marguerite Lepoulain Doubliez, Virginie Levrat, Chrystèle Locher, Sandrine Loutski-Vettese, Edith Maetz, Fanny Magne, Cécile Maincent, Alexa Mairovitz, Catherine Marichy, Nancy Marion, David Marquette, Bénédicte Martignac, Stéphanie Martinez, Clothilde Marty, Philippe Masson, Cyril Maurer, Vincent Meniai, Geoffroy Milliet De Faverges, Olivier Molinier, Isabelle Monnet, Lionel Moreau, Hugues Morel, Laurent Mosser, Anne-Catherine Neidhardt, David Nunes, Julie Obert, Vanessa Pante, Magalie Paysse, Herve Pegliasco, Jean-Michel Peloni, Christophe Perrin, Lidia Petit, Marjorie Picaud, Julian Pinsolle, Mihai Popa, Laurent Portel, Jean Quieffin, Hong Rabut, Élise Redureau, David Renault, Patrick Aldo Renault, Claudia Rizzo, Maud Russier, Marielle Sabatini, Thierry Saelens, Sophie Schneider, Philippe Slaouti, Luc Stoven, Vincent Tack, Jean-Yves Tavernier, Dorine Templement-Grangerat, Laurence Thirard, Séverine Thomassin, Marie Tiercin, Jean Tredaniel, Andreea Tudor, Amélie Turlotte, Colette Vincent, Jérôme Virally

Affiliations

¹ Respiratory Medicine Department, Groupe Hospitalier de la Région Mulhouse Sud-Alsace, Hôpital Emile Muller, Mulhouse, France.
² Respiratory Medicine Department, Centre Hospitalier Le Mans, Le Mans, France.
³ Respiratory Medicine Department, L'Hôpital Nord-Ouest, Villefranche-Sur-Saône, France.
⁴ Respiratory Medicine Department, Grand Hôpital de l'Est Francilien (GHEF), Meaux, France.
⁵ Respiratory Medicine Department, Centre Hospitalier Annecy Genevois (CHANGE), Annecy, France.
⁶ Biostatistician, Public Health Department, CHU de Strasbourg, GMRC, Strasbourg, France.
⁷ Respiratory Medicine Department, Centre Hospitalier Régional D'Orléans Hôpital de La Source, Orléans, France.
⁸ Respiratory Medicine Department, Hôpital de Cannes Simone Veil, Cannes, France.
⁹ Methodologist, Groupe Statistique, ARCAGY - GINECO, Paris, France.
¹⁰ Biostatistician, QualityStat, Morangis, France.
¹¹ Department of Thoracic Oncology, Groupe hospitalier Paris-Saint Joseph, Paris, France.
¹² Respiratory Medicine Department, Centre Hospitalier Intercommunal Créteil, Créteil, France.
¹³ Respiratory Medicine Department, Hôpital d'Instruction des Armées Sainte-Anne, Toulon, France.
¹⁴ Respiratory Medicine Department, Centre Hospitalier de Colmar, Colmar, France.
¹⁵ Respiratory Medicine Department, Centre Hospitalier de Cornouaille, Quimper, France.
¹⁶ Respiratory Medicine Department, Centre Hospitalier de Lyon Sud, Hospices Civils de Lyon, Lyon, France.
¹⁷ Department of Thoracic Oncology, CHU de Lille, CNRS, Inserm, Institut Pasteur de Lille, UMR9020-U1277-CANTHER, Lille, France.

Abstract

Background: Long-term changes in lung cancer (LC) patients are difficult to evaluate. We report results from the French KBP-2020 real-life cohort.

Methods: KBP-2020 was a prospective cohort that included all patients diagnosed with LC in 2020, in nonacademic public hospital in France. Patient and tumour characteristics were described and compared with similarly designed cohorts in 2000 and 2010.

Findings: In 2020, 82 centers included 8,999 patients diagnosed with LC. The proportion of women increased: 34·6% (3114/8999) compared to, 24·3% (1711/7051) and 16·0% (904/5667) in 2010 and 2000 (p<0·0001). The proportion of non-smokers was higher in 2020 (12·6%, 1129/8983) than in previous cohorts (10·9% (762/7008) in 2010; 7·2% (402/5586) in 2000, p<0·0001). In 2020, at diagnosis, 57·6% (4405/7648) of patients had a metastatic/disseminated stage non-small-cell lung cancer (NSCLC) (58·3% (3522/6046) in 2010; 42·6% (1879/4411) in 2000, p<0·0001). Compared with 2000 and 2010 data, early survival improved slightly. In 2020, 3-month mortality of NSCLC varied from 3·0% [2·2 - 3·8] for localized to 9·6% [8·1 - 11·0] for locally advanced to 29·2% [27·8 - 30·6] for metastatic and was 24·8% [22·3 - 27·3] for SCLC.

Interpretation: To our knowledge KBP cohorts have been the largest, prospective, real-world cohort studies involving LC patients conducted in worldwide. The trend found in our study shows an increase in LC in women and still a large proportion of patients diagnosed at metastatic or disseminated stage.

Funding: The study was promoted by the French College of General Hospital Pulmonologists with financial support of industrials laboratories.

Keywords: Adenocarcinoma; CPHG, French College of General Hospital Pulmonologists; Early mortality; Epidemiology; LC, Lung Cancer; Lung cancer; NPH, Nonacademic public hospitals; NSCLC, Non-small-cell lung cancer; Non-small-cell lung cancer; PS, Performance status; Real-life; SCLC, Small-cell lung cancer; Small-cell lung cancer; Smoking habits; TMB, Tumour molecular burden; Tumor characteristics.