Capnography in newborns under mechanical ventilation and its relationship with the measurement of CO₂ in blood samples

Introduction: Monitoring the partial pressure of CO₂ (PCO₂) in newborns who require ventilation would allow avoiding hypocapnia and hypercapnia. The measurement of end-tidal carbon dioxide (ETCO₂) is an alternative rarely implemented in this population.

Objective: To evaluate the relationship between ETCO₂ and PCO₂ in newborns.

Methods: Cross-sectional study comparing two PCO₂ measurement methods, the conventional one by analysis of blood samples and the one estimated by ETCO₂. The study included hospitalized newborns that required conventional mechanical ventilation. The ETCO₂ was measured with a Tecme GraphNet® neo, a neonatal ventilator with an integrated capnograph, and we obtained the ETCO₂-PCO₂ gradient. We conducted correlation and Bland-Altman plot analyses to estimate the agreement.

Results: A total of 277 samples (ETCO₂ / PCO₂) from 83 newborns were analyzed. The mean values ​​of ETCO₂ and PCO₂ were 41.36mmHg and 42.04mmHg. There was a positive and significant correlation between ETCO₂ and PCO₂ in the overall analysis (r=0.5402; P<.001) and in the analysis of each unit (P<.001). The mean difference was 0.68 mmHg (95% CI, -0.68 to 1.95) and was not significant. We observed a positive systematic error (PCO₂ > ETCO₂) in 2 of the units, and a negative difference in the third (PCO₂ < ETCO₂).

Discussion: The correlation between ETCO and PCO₂ was significant, although the obtained values ​​were not equivalent, with differences ranging from 0.1mmHg and 20mmHg. Likewise, we found systematic errors that differed in sign (positive or negative) between institutions.