Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Jinyuan Zhang; Kyunghun Kim; Ho Joong Kim; Dawn Meyer; Woohyun Park; Seul Ah Lee; Yumin Dai; Bongjoong Kim; Haesoo Moon; Jay V Shah; Keely E Harris; Brett Collar; Kangying Liu; Pedro Irazoqui; Hyowon Lee; Shin Ae Park; Pete S Kollbaum; Bryan W Boudouris; Chi Hwan Lee

doi:10.1038/s41467-022-33254-4

Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Nat Commun. 2022 Sep 20;13(1):5518. doi: 10.1038/s41467-022-33254-4.

Authors

Jinyuan Zhang^#¹, Kyunghun Kim^#¹, Ho Joong Kim^#², Dawn Meyer³, Woohyun Park⁴, Seul Ah Lee¹, Yumin Dai⁵, Bongjoong Kim^{1

6}, Haesoo Moon¹, Jay V Shah⁷, Keely E Harris⁸, Brett Collar⁹, Kangying Liu¹⁰, Pedro Irazoqui⁹, Hyowon Lee^{1

11

12}, Shin Ae Park¹³, Pete S Kollbaum^{14

15}, Bryan W Boudouris^{16

17

18}, Chi Hwan Lee^{19

20

21

22

23

24}

Affiliations

¹ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
² Charles D. Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, USA.
³ School of Optometry, Indiana University, Bloomington, IN, USA.
⁴ School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
⁵ School of Materials Engineering, Purdue University, West Lafayette, IN, USA.
⁶ Department of Mechanical and System Design Engineering, Hongik University, Seoul, 04066, Republic of Korea.
⁷ Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, USA.
⁸ Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA.
⁹ Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
¹⁰ Department of Chemistry, Purdue University, West Lafayette, IN, USA.
¹¹ Center for Implantable Devices, Purdue University, West Lafayette, IN, USA.
¹² Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA.
¹³ Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA. [email protected].
¹⁴ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. [email protected].
¹⁵ School of Optometry, Indiana University, Bloomington, IN, USA. [email protected].
¹⁶ Charles D. Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, USA. [email protected].
¹⁷ Department of Chemistry, Purdue University, West Lafayette, IN, USA. [email protected].
¹⁸ Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA. [email protected].
¹⁹ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. [email protected].
²⁰ School of Optometry, Indiana University, Bloomington, IN, USA. [email protected].
²¹ School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA. [email protected].
²² School of Materials Engineering, Purdue University, West Lafayette, IN, USA. [email protected].
²³ Center for Implantable Devices, Purdue University, West Lafayette, IN, USA. [email protected].
²⁴ Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA. [email protected].

^# Contributed equally.

Abstract

Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Animals
Contact Lenses, Hydrophilic*
Dogs
Glaucoma* / therapy
Humans
Intraocular Pressure
Oxygen
Rabbits
Tonometry, Ocular

Substances

Oxygen

Grants and funding

K08 EY030950/EY/NEI NIH HHS/United States