A nomenclature consensus for nervous system organoids and assembloids

Sergiu P Pașca; Paola Arlotta; Helen S Bateup; J Gray Camp; Silvia Cappello; Fred H Gage; Jürgen A Knoblich; Arnold R Kriegstein; Madeline A Lancaster; Guo-Li Ming; Alysson R Muotri; In-Hyun Park; Orly Reiner; Hongjun Song; Lorenz Studer; Sally Temple; Giuseppe Testa; Barbara Treutlein; Flora M Vaccarino

doi:10.1038/s41586-022-05219-6

A nomenclature consensus for nervous system organoids and assembloids

Nature. 2022 Sep;609(7929):907-910. doi: 10.1038/s41586-022-05219-6. Epub 2022 Sep 28.

Authors

Sergiu P Pașca^{1

2}, Paola Arlotta^{3

4}, Helen S Bateup^{5

6

7}, J Gray Camp^{8

9}, Silvia Cappello¹⁰, Fred H Gage¹¹, Jürgen A Knoblich^{12

13}, Arnold R Kriegstein^{14

15}, Madeline A Lancaster¹⁶, Guo-Li Ming^{17

18

19

20

21}, Alysson R Muotri^{22

23}, In-Hyun Park²⁴, Orly Reiner²⁵, Hongjun Song^{17

18

19

20

26}, Lorenz Studer²⁷, Sally Temple²⁸, Giuseppe Testa^{29

30}, Barbara Treutlein³¹, Flora M Vaccarino^{32

33

34}

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. [email protected].
² Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute and Bio-X, Stanford University, Stanford, CA, USA. [email protected].
³ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
⁴ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
⁶ Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
⁷ Chan Zuckerberg Biohub, San Francisco, CA, USA.
⁸ Roche Institute for Translational Bioengineering, Basel, Switzerland.
⁹ University of Basel, Basel, Switzerland.
¹⁰ Max Planck Institute of Psychiatry, Munich, Germany.
¹¹ Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
¹² Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
¹³ Department of Neurology, Medical University of Vienna, Vienna, Austria.
¹⁴ Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
¹⁵ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
¹⁶ MRC Laboratory of Molecular Biology, Cambridge, UK.
¹⁷ Department of Neuroscience, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁸ Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁹ Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²⁰ Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²¹ Department of Psychiatry, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²² Departments of Pediatrics and Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
²³ Stem Cell Program, Archealization Center, Center for Academic Research and Training in Anthropogeny, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
²⁴ Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
²⁵ Weizmann Institute of Science, Rehovot, Israel.
²⁶ The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²⁷ The Center for Stem Cell Biology, Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.
²⁸ Neural Stem Cell Institute, Rensselaer, NY, USA.
²⁹ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
³⁰ Human Technopole, Milan, Italy.
³¹ Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
³² Child Study Center, Yale University, New Haven, CT, USA.
³³ Department of Neuroscience, Yale University, New Haven, CT, USA.
³⁴ Yale Kavli Institute for Neuroscience, New Haven, CT, USA.

Abstract

Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to provide insights into how the human nervous system develops, what makes it unique and how disorders of the nervous system arise, progress and could be treated. Here, to facilitate progress and improve communication with the scientific community and the public, we clarify and provide a basic framework for the nomenclature of human multicellular models of nervous system development and disease, including organoids, assembloids and transplants.

MeSH terms

Consensus*
Humans
Models, Biological
Nervous System* / cytology
Nervous System* / pathology
Organoids* / cytology
Organoids* / pathology
Pluripotent Stem Cells / cytology
Terminology as Topic*

Abstract

MeSH terms

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