Osteoarthritis Progression: Mitigation and Rehabilitation Strategies

Devin Drummer; Jeremy McAdam; Regina Seay; Arny Ferrando; S Louis Bridges Jr; Jasvinder A Singh; Marcas Bamman

doi:10.3389/fresc.2021.724052

Osteoarthritis Progression: Mitigation and Rehabilitation Strategies

Front Rehabil Sci. 2021 Aug 23:2:724052. doi: 10.3389/fresc.2021.724052. eCollection 2021.

Authors

Devin Drummer^{1

2}, Jeremy McAdam^{1

2}, Regina Seay^{1

2}, Arny Ferrando³, S Louis Bridges Jr^{4

5}, Jasvinder A Singh^{6

7

8}, Marcas Bamman^{1

2

9}

Affiliations

¹ UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
² Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
³ Department of Geriatrics and Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
⁴ Department of Medicine, Hospital for Special Surgery, New York, NY, United States.
⁵ Division of Rheumatology, Weill Cornell Medical Center, New York, NY, United States.
⁶ Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, United States.
⁷ Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, United States.
⁸ Veterans Affairs Medical Center, Birmingham, AL, United States.
⁹ Florida Institute for Human and Machine Cognition, Pensacola, FL, United States.

Abstract

Osteoarthritis is the most common form of arthritis and is a substantial burden for patients with the disease. Currently, there is no cure for osteoarthritis, but many emerging therapies have been developed to aid in the mitigation of disease progression. When osteoarthritis reaches the end-stage of disease many patients undergo total joint arthroplasty to improve quality of life, yet some experience persistent pain and mobility limitations for extended periods following surgery. This review highlights recent therapeutic advancements in osteoarthritis treatment consisting of pharmacologics, nutraceuticals, biologics, and exercise while emphasizing the current state of post-arthroplasty rehabilitation.

Keywords: exercise; osteoarthritis; rehabilitation; therapeutics; total joint arthroplasty.

Publication types

Review

Abstract

Publication types

Grants and funding