PEARLS - A multicentre phase II/III trial of extended field radiotherapy for androgen sensitive prostate cancer patients with PSMA-avid pelvic and/or para-aortic lymph nodes at presentation

Julia Murray; Clare Cruickshank; Thomas Bird; Philip Bell; John Braun; Dave Chuter; Miguel Reis Ferreira; Clare Griffin; Shama Hassan; Nabil Hujairi; Alan Melcher; Elizabeth Miles; Olivia Naismith; Miguel Panades; Lara Philipps; Alison Reid; Jan Rekowski; Pete Sankey; John Staffurth; Isabel Syndikus; Alison Tree; Anna Wilkins; Emma Hall; PEARLS Trial Management Group

doi:10.1016/j.ctro.2022.09.003

PEARLS - A multicentre phase II/III trial of extended field radiotherapy for androgen sensitive prostate cancer patients with PSMA-avid pelvic and/or para-aortic lymph nodes at presentation

Clin Transl Radiat Oncol. 2022 Sep 24:37:130-136. doi: 10.1016/j.ctro.2022.09.003. eCollection 2022 Nov.

Authors

Julia Murray^{1

2}, Clare Cruickshank², Thomas Bird³, Philip Bell⁴, John Braun⁵, Dave Chuter^{4

6}, Miguel Reis Ferreira⁷, Clare Griffin², Shama Hassan², Nabil Hujairi¹, Alan Melcher^{1

2}, Elizabeth Miles⁸, Olivia Naismith⁹, Miguel Panades¹⁰, Lara Philipps^{1

2}, Alison Reid¹, Jan Rekowski², Pete Sankey¹¹, John Staffurth¹², Isabel Syndikus¹³, Alison Tree^{1

2}, Anna Wilkins^{1

2}, Emma Hall²; PEARLS Trial Management Group

Affiliations

¹ The Royal Marsden NHS Foundation Trust, London, UK.
² The Institute of Cancer Research, London, UK.
³ University Hospitals Bristol & Weston NHS Foundation Trust, Bristol, UK.
⁴ NCRI Consumer Forum, London, UK.
⁵ RMH Radiotherapy Focus Group & RMH Biomedical Research Centre Consumer Group, Sutton, UK.
⁶ NCRI Living With & Beyond Cancer (Acute and Toxicities Workstream), London, UK.
⁷ Guys & St Thomas NHS Trust and King's College, London, UK.
⁸ Radiotherapy Trials QA Group (RTTQA), Mount Vernon Hospital, Northwood, UK.
⁹ Radiotherapy Trials QA Group (RTTQA), Royal Marsden NHS Foundation Trust, London, UK.
¹⁰ United Lincolnshire Hospitals NHS Trust, Lincoln, UK.
¹¹ University Hospitals Plymouth NHS Trust, Plymouth, UK.
¹² Velindre University NHS Trust and Cardiff University, Cardiff, UK.
¹³ Clatterbridge Cancer Centre, Wirral, UK.

Abstract

PEARLS is a multi-stage randomised controlled trial for prostate cancer patients with pelvic and/or para-aortic PSMA-avid lymph node disease at presentation. The aim of the trial is to determine whether extending the radiotherapy field to cover the para-aortic lymph nodes (up to L1/L2 vertebral interspace) can improve outcomes for this patient group.

Keywords: IMRT; PSMA-PET; Para-aortic lymph nodes; Prostate; Randomized controlled trial.

Abstract

Grants and funding