Successful fractionated undiluted doses of COVID-19 vaccine in five cases of suspected allergic reactions to the first dose

Federica Rivolta; Cappelletti Camilla; Andrea Sangalli; Alessandra Chiei Gallo; Valerio Pravettoni

doi:10.1002/ccr3.6348

Successful fractionated undiluted doses of COVID-19 vaccine in five cases of suspected allergic reactions to the first dose

Clin Case Rep. 2022 Oct 11;10(10):e6348. doi: 10.1002/ccr3.6348. eCollection 2022 Oct.

Authors

Federica Rivolta¹, Cappelletti Camilla², Andrea Sangalli², Alessandra Chiei Gallo², Valerio Pravettoni¹

Affiliations

¹ UOC General Medicine Immunology and Allergology Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy.
² Allergy and Clinical Immunology Residency University of Milan Milan Italy.

Abstract

After a suspected allergic reaction to first dose of mRNA COVID-19 vaccine, given the PEG skin tests negativity and tolerance in vivo to PEG containing drugs, five patients were vaccinated with the second dose of Pfizer-Biontech undergoing a fractional protocol, with antihistamine premedication, without presenting immediate or delayed reactions.

Keywords: COVID‐19; COVID‐19 vaccine allergic reaction; allergy; anaphylaxis; mRNA vaccine; polyethylene glycol; vaccine; vaccine side effects.

Publication types

Case Reports