The correlation between COVID-19 segmentation volume based on artificial intelligence technology and gastric wall edema: a multi-center study in Wuhan

Xiaoming Li; Fengxi Chen; Jie Cheng; Yiman Li; Jun Wang; Jian Wang; Chen Liu

doi:10.1007/s42058-022-00104-7

The correlation between COVID-19 segmentation volume based on artificial intelligence technology and gastric wall edema: a multi-center study in Wuhan

Chin J Acad Radiol. 2022;5(4):223-231. doi: 10.1007/s42058-022-00104-7. Epub 2022 Oct 11.

Authors

Xiaoming Li^#¹, Fengxi Chen^#¹, Jie Cheng¹, Yiman Li¹, Jun Wang², Jian Wang¹, Chen Liu¹

Affiliations

¹ Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038 China.
² School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

^# Contributed equally.

Abstract

Purpose: This study aimed to investigate manifestations of the gastric wall and related risk factors in COVID-19 patients with gastrointestinal symptoms by CT.

Materials and methods: Two hundred and forty patients diagnosed with COVID-19 by RT-PCR were enrolled from January 2020 to April 2020. Patients showed gastrointestinal symptoms, including nausea, vomiting, or diarrhea. Results of the initial laboratory examination were performed after admission. Chest CT was performed for all patients, with the lower bound including the gastric antrum. The volume of COVID-19 and lungs was segmented, and the ratio was calculated as follows: PV/LV = Volume_pneumonia/Volume_lungs.

Results: Among the 240 patients, 109 presented with gastric wall edema (edema group), and 131 showed no gastric wall edema (non-edema group); the PV/LV values between the two groups were significantly different (P = 0.002). Univariate analysis revealed the following: fibrinogen (Fib), thrombin time (TT), activated partial thromboplastin time (APTT), and albumin (ALB) significantly differed between the two groups (P < 0.05). Binary logistic regression analysis showed that only APTT had a negative effect on gastric wall edema (P = 0.003).

Conclusions: SARS-CoV-2 invades the gastrointestinal tract, gastric wall edema is the primary CT manifestation, and gastric wall edema is more likely to occur with a shorter APTT and severe pneumonia, with a slightly longer hospitalization time. Patients with gastric wall edema observed by CT should intervene early, which may improve digestive function, and further strengthen immune potency against COVID-19.

Keywords: COVID-19; Edema; Gastrointestinal symptoms; Imaging; SARS-CoV-2.

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