Imaging mass cytometry: High-dimensional and single-cell perspectives on the microenvironment of solid tumours

Zehan Liu; Jing Xun; Shuangqing Liu; Botao Wang; Aimin Zhang; Lanqiu Zhang; Ximo Wang; Qi Zhang

doi:10.1016/j.pbiomolbio.2022.10.003

Imaging mass cytometry: High-dimensional and single-cell perspectives on the microenvironment of solid tumours

Prog Biophys Mol Biol. 2022 Nov:175:140-146. doi: 10.1016/j.pbiomolbio.2022.10.003. Epub 2022 Oct 15.

Authors

Zehan Liu¹, Jing Xun², Shuangqing Liu³, Botao Wang³, Aimin Zhang⁴, Lanqiu Zhang², Ximo Wang⁵, Qi Zhang⁶

Affiliations

¹ Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300070, China; Section for HepatoPancreatoBiliary Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China.
² Tianjin ITCWM Clinical Research Centre, Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China.
³ Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300070, China.
⁴ Clinical Laboratory of Tianjin Nankai Hospital,Tianjin, 300100, China.
⁵ Tianjin ITCWM Clinical Research Centre, Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China. Electronic address: [email protected].
⁶ Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300070, China; Tianjin ITCWM Clinical Research Centre, Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China. Electronic address: [email protected].

PMID: 36252872
DOI: 10.1016/j.pbiomolbio.2022.10.003

Abstract

Imaging mass cytometry (IMC) is a new technology integrating mass spectrometry, high-resolution laser ablation and immunohistochemistry/cytochemistry. A unique high-dimensional perspective comprehensively and accurately depicts the complex interaction of phenotype, signalling pathway and tumour microenvironment and is widely used in solid tumours. However, the application scenarios of IMC in basic medicine and clinical research in solid tumours lack systematic introduction and classification. This paper reviews the application of IMC in depicting the panorama of the tumour microenvironment, revealing tumour spatial heterogeneity, clarifying tumour pharmacological mechanisms, assisting in new drug development, and dynamically evaluating the efficacy of immunotherapy in solid tumours.

Keywords: Imaging mass cytometry; Immunotherapy; Tumour heterogeneity; Tumour microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Image Cytometry
Immunotherapy
Neoplasms* / pathology
Signal Transduction
Tumor Microenvironment*