Peroxynitrite promotes immune evasion by reducing tumor antigenicity

Cell Rep Med. 2022 Oct 18;3(10):100787. doi: 10.1016/j.xcrm.2022.100787.

Abstract

A study by Tcyganov et al.1 demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficacy preclinically.

Publication types

  • Comment

MeSH terms

  • Antigens, Neoplasm / therapeutic use
  • Histocompatibility Antigens Class I
  • Humans
  • Immune Checkpoint Inhibitors
  • Immune Evasion*
  • Neoplasms* / drug therapy
  • Oxidants / therapeutic use
  • Peptides / therapeutic use
  • Peroxynitrous Acid / therapeutic use
  • Tumor Microenvironment

Substances

  • Peroxynitrous Acid
  • Immune Checkpoint Inhibitors
  • Antigens, Neoplasm
  • Histocompatibility Antigens Class I
  • Peptides
  • Oxidants