Fishing for a balance: Toward promyelinating drug discovery

Hannah Y Collins; Ben Emery

doi:10.1016/j.chembiol.2022.09.005

Fishing for a balance: Toward promyelinating drug discovery

Cell Chem Biol. 2022 Oct 20;29(10):1467-1469. doi: 10.1016/j.chembiol.2022.09.005.

Authors

Hannah Y Collins¹, Ben Emery²

Affiliations

¹ Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR 97239, USA; Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
² Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: [email protected].

PMID: 36270232
DOI: 10.1016/j.chembiol.2022.09.005

Abstract

In this issue, Häberlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish receptor. These findings highlight the potential for humanized zebrafish as an in vivo platform for targeted remyelination drug screens.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Drug Discovery
Nerve Tissue Proteins
Oligodendroglia*
Zebrafish*

Substances

Nerve Tissue Proteins