Recent advances in graves ophthalmopathy medical therapy: a comprehensive literature review

Int Ophthalmol. 2023 Apr;43(4):1437-1449. doi: 10.1007/s10792-022-02537-6. Epub 2022 Oct 22.

Abstract

Graves ophthalmopathy (GO), which occurs in autoimmune thyroid disease, can reduce patients' quality of life due to its impact on visual function, physical appearance, and emotional health. Corticosteroids have been the first-line treatment for GO. More recently, the pathogenesis of GO has made significant progress. Various targeting biological agents and immunosuppressive agents make GO management more promising. Fully understanding GO pathogenesis and precise clinical management are beneficial for the prognosis of patients. Therefore, we conducted a comprehensive review of the medical management of GO and summarized research developments to highlight future research issues.

Keywords: Diagnosis; Graves ophthalmopathy; Management; Thyroid-associated ophthalmopathy.

Publication types

  • Review

MeSH terms

  • Graves Ophthalmopathy* / diagnosis
  • Graves Ophthalmopathy* / drug therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Quality of Life

Substances

  • Immunosuppressive Agents