Demonstration of growth-inhibitory as well as growth-stimulatory factors in medium conditioned by lung lavage cells stimulated with a chemotactic factor secreted by jaagsiekte tumour cells

Onderstepoort J Vet Res. 1987 Jun;54(2):123-30.

Abstract

Both growth-inhibitory and growth-stimulatory factors were detected in vitro in medium from chemotactically stimulated cultures of lung lavage cells. The macrophage component of the lavage cells was found to produce a growth stimulatory factor that was replaced by a growth inhibitory factor following chemotactic factor stimulation.

MeSH terms

  • Animals
  • Cells, Cultured
  • Chemotactic Factors / metabolism*
  • Growth Inhibitors / metabolism*
  • Growth Substances / biosynthesis*
  • Macrophages*
  • Pulmonary Adenomatosis, Ovine / metabolism*
  • Pulmonary Alveoli / pathology
  • Sheep

Substances

  • Chemotactic Factors
  • Growth Inhibitors
  • Growth Substances