Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Drug Resist Updat. 2022 Dec:65:100885. doi: 10.1016/j.drup.2022.100885. Epub 2022 Oct 20.

Abstract

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

Keywords: Aspergillus fumigatus; DHODH inhibitor; One Health; olorofim; triazole resistance.

MeSH terms

  • Agriculture
  • Antifungal Agents* / pharmacology
  • Antifungal Agents* / therapeutic use
  • Aspergillus fumigatus
  • Azoles
  • Drug Resistance, Fungal
  • Fungicides, Industrial* / pharmacology
  • Fungicides, Industrial* / therapeutic use
  • Humans
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents
  • Fungicides, Industrial
  • Azoles