[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis]

G P Arutyunov; E I Tarlovskaya; A G Arutyunov; Y N Belenkov; A O Konradi; Y M Lopatin; A P Rebrov; S N Tereshchenko; A I Chesnikova; H G Hayrapetyan; A P Babin; I G Bakulin; N V Bakulina; L A Balykova; A S Blagonravova; M V Boldina; A R Vaisberg; A S Galyavich; V V Gomonova; N Y Grigorieva; I V Gubareva; I V Demko; A V Evzerikhina; A V Zharkov; U K Kamilova; Z F Kim; T Y Kuznetsova; N V Lareva; E V Makarova; S V Malchikova; S V Nedogoda; M M Petrova; I G Pochinka; K V Protasov; D N Protsenko; D Y Ruzanau; S A Sayganov; A S Sarybaev; N M Selezneva; A B Sugraliev; I V Fomin; O V Khlynova; O Y Chizhova; I I Shaposhnik; D A Sh'ukarev; А K Abdrahmanova; S A Avetisian; H G Avoyan; K K Azarian; G T Aimakhanova; D A Ayipova; A C Akunov; M K Alieva; A V Aparkina; O R Aruslanova; E Y Ashina; O Y Badina; O Y Barisheva; A S Batchayeva; A M Bitieva; I U Bikhteyev; N A Borodulina; M V Bragin; A M Budu; G M Bykova; K R Vagapova; D D Varlamova; N N Vezikova; E A Verbitskaya; O E Vilkova; E A Vinnikova; V V Vustina; E A Galova; V V Genkel; E I Gorshenina; R V Gostishev; E V Grigorieva; E Y Gubareva; G M Dabylova; A I Demchenko; O Y Dolgikh; M Y Duyshobayev; D S Evdokimov; K E Egorova; A N Ermilova; A E Zheldybayeva; N V Zarechnova; Y D Zimina; S Y Ivanova; E Y Ivanchenko; M V Ilina; M V Kazakovtseva; E V Kazymova; Y S Kalinina; N A Kamardina; A M Karachenova; I A Karetnikov; N A Karoli; M K Karsiev; D S Кaskaeva; K F Kasymova; Z B Kerimbekova; A S Kerimova; E S Kim; N V Kiseleva; D A Klimenko; A V Klimova; O V Kovalishena; E V Kolmakova; T P Kolchinskaya; M I Kolyadich; O V Kondriakova; M P Konoval; D Y Konstantinov; E A Konstantinova; V A Kordukova; E V Koroleva; A Y Kraposhina; T V Kriukova; A S Kuznetsova; T Y Kuzmina; K V Kuzmichev; C K Kulchoroevna; T V Kuprina; I M Kouranova; L V Kurenkova; N Y Kurchugina; N A Kushubakova; V I Levankova; N A Lyubavina; N A Magdeyeva; K V Mazalov; V I Majseenko; A S Makarova; A M Maripov; A A Marusina; E S Melnikov; N B Moiseenko; F N Muradova; R G Muradyan; S N Musaelian; A O Myshak; E S Nekaeva; N M Nikitina; B B Ogurlieva; A A Odegova; Y V Omarova; N A Omurzakova; S O Ospanova; E V Pahomova; L D Petrov; S S Plastinina; V A Pogrebetskaya; D S Polyakov; E V Ponomarenko; L L Popova; N A Prokofeva; I A Pudova; N A Rakov; A N Rahimov; N A Rozanova; S Serikbolkyzy; A A Simonov; V V Skachkova; D V Soloveva; I A Soloveva; A K Subbotin; I M Sukhomlinova; A G Sushilova; D R Tagayeva; Y V Titojkina; E P Tikhonova; D S Tokmin; A A Tolmacheva; M S Torgunakova; K V Trenogina; N A Trostianetckaia; D A Trofimov; A A Tulichev; A T Tursunova; N D Ulanova; O V Fatenkov; O V Fedorishina; T S Fil; I Y Fomina; I S Fominova; I A Frolova; S M Tsvinger; V V Tsoma; M B Cholponbaeva; T I Chudinovskikh; O A Shevchenko; T V Sheshina; E A Shishkina; K Y Shishkov; S Y Sherbakov; E A Yausheva

doi:10.26442/00403660.2022.01.201320

[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis]

Ter Arkh. 2022 Jan 15;94(1):32-47. doi: 10.26442/00403660.2022.01.201320.

[Article in Russian]

Authors

G P Arutyunov^{1

2}, E I Tarlovskaya^{1

3}, A G Arutyunov^{1

2}, Y N Belenkov⁴, A O Konradi⁵, Y M Lopatin⁶, A P Rebrov⁷, S N Tereshchenko⁸, A I Chesnikova⁹, H G Hayrapetyan¹⁰, A P Babin¹¹, I G Bakulin¹², N V Bakulina¹², L A Balykova¹³, A S Blagonravova³, M V Boldina³, A R Vaisberg³, A S Galyavich^{14

15}, V V Gomonova¹², N Y Grigorieva¹⁶, I V Gubareva¹⁷, I V Demko¹⁸, A V Evzerikhina¹⁹, A V Zharkov²⁰, U K Kamilova²¹, Z F Kim²², T Y Kuznetsova²³, N V Lareva²⁴, E V Makarova³, S V Malchikova²⁵, S V Nedogoda⁶, M M Petrova²⁶, I G Pochinka^{3

27}, K V Protasov²⁸, D N Protsenko²⁹, D Y Ruzanau³⁰, S A Sayganov¹², A S Sarybaev³¹, N M Selezneva¹³, A B Sugraliev³², I V Fomin³, O V Khlynova³³, O Y Chizhova¹², I I Shaposhnik³⁴, D A Sh'ukarev²⁰, А K Abdrahmanova^{35

36}, S A Avetisian¹⁰, H G Avoyan¹⁰, K K Azarian¹⁰, G T Aimakhanova³², D A Ayipova³¹, A C Akunov³¹, M K Alieva¹², A V Aparkina³⁷, O R Aruslanova³⁸, E Y Ashina³, O Y Badina³⁹, O Y Barisheva²³, A S Batchayeva², A M Bitieva¹², I U Bikhteyev¹², N A Borodulina³⁸, M V Bragin¹², A M Budu⁴⁰, G M Bykova³³, K R Vagapova⁴¹, D D Varlamova²³, N N Vezikova²³, E A Verbitskaya²⁶, O E Vilkova¹⁶, E A Vinnikova¹², V V Vustina⁴², E A Galova³, V V Genkel³⁴, E I Gorshenina¹³, R V Gostishev²⁹, E V Grigorieva⁷, E Y Gubareva¹⁷, G M Dabylova³², A I Demchenko¹⁷, O Y Dolgikh⁴³, M Y Duyshobayev³¹, D S Evdokimov¹², K E Egorova⁴⁴, A N Ermilova^{1

45}, A E Zheldybayeva³², N V Zarechnova³⁹, Y D Zimina⁴⁶, S Y Ivanova⁴⁷, E Y Ivanchenko³, M V Ilina⁴⁸, M V Kazakovtseva²⁵, E V Kazymova⁴⁹, Y S Kalinina²⁶, N A Kamardina³⁹, A M Karachenova⁵⁰, I A Karetnikov⁵¹, N A Karoli⁷, M K Karsiev¹², D S Кaskaeva²⁶, K F Kasymova²⁶, Z B Kerimbekova³¹, A S Kerimova²⁹, E S Kim^{15

22}, N V Kiseleva³, D A Klimenko¹⁷, A V Klimova^{52

2}, O V Kovalishena³, E V Kolmakova¹², T P Kolchinskaya⁴⁰, M I Kolyadich^{34

40}, O V Kondriakova¹⁷, M P Konoval¹², D Y Konstantinov¹⁷, E A Konstantinova¹⁷, V A Kordukova³, E V Koroleva⁵³, A Y Kraposhina^{18

26}, T V Kriukova⁵⁴, A S Kuznetsova³⁴, T Y Kuzmina²⁶, K V Kuzmichev⁵⁵, C K Kulchoroevna³¹, T V Kuprina²³, I M Kouranova⁵⁶, L V Kurenkova⁵⁷, N Y Kurchugina¹⁷, N A Kushubakova⁵⁸, V I Levankova⁵⁹, N A Lyubavina³, N A Magdeyeva³⁷, K V Mazalov³⁹, V I Majseenko³⁰, A S Makarova²⁸, A M Maripov³¹, A A Marusina⁴⁸, E S Melnikov^{1

12}, N B Moiseenko¹⁶, F N Muradova³, R G Muradyan⁶⁰, S N Musaelian⁶¹, A O Myshak⁶², E S Nekaeva³, N M Nikitina³⁷, B B Ogurlieva^{2

63}, A A Odegova²⁵, Y V Omarova³, N A Omurzakova⁵⁸, S O Ospanova³², E V Pahomova⁶⁴, L D Petrov⁶⁵, S S Plastinina³, V A Pogrebetskaya⁶⁶, D S Polyakov³, E V Ponomarenko⁶⁷, L L Popova¹⁷, N A Prokofeva¹², I A Pudova^{3

68}, N A Rakov³, A N Rahimov²¹, N A Rozanova⁶⁹, S Serikbolkyzy³², A A Simonov¹², V V Skachkova⁴², D V Soloveva³, I A Soloveva^{18

26}, A K Subbotin³⁹, I M Sukhomlinova⁴⁷, A G Sushilova¹², D R Tagayeva²¹, Y V Titojkina¹³, E P Tikhonova²⁶, D S Tokmin⁷⁰, A A Tolmacheva^{71

72}, M S Torgunakova²⁶, K V Trenogina⁴², N A Trostianetckaia¹², D A Trofimov^{15

22}, A A Tulichev^{3

73}, A T Tursunova³², N D Ulanova⁵⁵, O V Fatenkov¹⁷, O V Fedorishina²⁸, T S Fil¹², I Y Fomina^{3

74}, I S Fominova¹³, I A Frolova³⁹, S M Tsvinger⁷⁵, V V Tsoma⁶, M B Cholponbaeva⁵⁸, T I Chudinovskikh²⁵, O A Shevchenko⁷⁶, T V Sheshina¹⁶, E A Shishkina⁷⁷, K Y Shishkov¹⁷, S Y Sherbakov⁷⁸, E A Yausheva¹³

Affiliations

¹ Eurasian Association of Therapists.
² Pirogov Russian National Research Medical University.
³ Privolzhsky Research Medical University.
⁴ Sechenov First Moscow State Medical University (Sechenov University).
⁵ Almazov National Medical Research Centre.
⁶ Volgograd State Medical University.
⁷ Saratov State Medical University named after V.I. Razumovsky.
⁸ National Medical Research Center of Cardiology.
⁹ Rostov State Medical University.
¹⁰ "Erebouni" Cardiology Center.
¹¹ Nicolae Testemitanu State University of Medicine and Pharmacy.
¹² Mechnikov North-Western State Medical University.
¹³ Ogarev Mordovia State University.
¹⁴ Republican Center for Cardiovascular Diseases of Interregional Clinical Diagnostic Center.
¹⁵ Kazan State Medical University.
¹⁶ Lobachevsky State University.
¹⁷ Samara State Medical University.
¹⁸ Regional Clinical Hospital.
¹⁹ Krasnogorsk City Hospital №1.
²⁰ Kirovsk Interdisrict Hospital.
²¹ Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation.
²² City Clinical Hospital №7.
²³ Petrozavodsk State University.
²⁴ Chita State Medical Academy.
²⁵ Kirov State Medical University.
²⁶ Voino-Yasenetsky Krasnoyarsk State Medical University.
²⁷ City Clinical Hospital №13 of.
²⁸ Irkutsk State Medical Academy of Postgraduate Education - Branch of Russian Medical Academy of Continuous Professional Education.
²⁹ Moscow City Clinical Hospital №40.
³⁰ Gomel State Medical University.
³¹ Mirrakhimov National Center of Cardiology and Therapy.
³² Asfendiyarov Kazakh National Medical University.
³³ Vagner Perm State Medical University.
³⁴ South Ural State Medical University.
³⁵ Kazakh Medical University of Continuing Education.
³⁶ Zhekenovа City Clinical Infectious Diseases Hospital.
³⁷ Razumovsky Saratov State Medical University.
³⁸ Clinical Cardiological Dispensary.
³⁹ The Volga District Medical Centre.
⁴⁰ City Clinical Hospital №1.
⁴¹ Polyclinic №1 of the President of the Russian Federation.
⁴² Perm Regional Clinical Hospital.
⁴³ Chapaevskaya Central City Hospital.
⁴⁴ Baranov Republic Hospital.
⁴⁵ Serbsky National Medical Research Centre for Psychiatry and Narcology.
⁴⁶ City Clinical Hospital №25.
⁴⁷ Hospital for Veterans.
⁴⁸ Polyclinic of Kirovsk Interdistrict Hospital.
⁴⁹ Clinical Hospital RZhD Meditsyna.
⁵⁰ Chita State Medical Academy, Chita.
⁵¹ Irkutsk Regional Сlinical Рospital.
⁵² Moscow City State Outpatient Hospital №134.
⁵³ City Сlinical Рospital №5.
⁵⁴ Association "Eurasian Association of Therapists".
⁵⁵ City Clinical Hospital №13 of Nizhnii Novgorod.
⁵⁶ Gorodetskaya Central District Hospital.
⁵⁷ Katkov Republic Clinical Hospital.
⁵⁸ National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
⁵⁹ City Polyclinic №1.
⁶⁰ Global Medical System Clinics and Hospitals.
⁶¹ Yerevan State Medical University.
⁶² Group of companies "Medinvestgroup".
⁶³ Moscow City Clinical Hospital №4.
⁶⁴ Republican tuberculosis dispensary.
⁶⁵ Health Center of Brichen.
⁶⁶ City Clinical Hospital №38.
⁶⁷ Medical center "Zimamed".
⁶⁸ Nizhniy Novgorod city Outpatient Hospital №4.
⁶⁹ Krasnogorsk city hospital №1.
⁷⁰ Labs of the Future.
⁷¹ Novosibirsk State Medical University.
⁷² Clinical Counselling and Diagnostic Polyclinic.
⁷³ SBHI of Nizhniy Novgorod region City Clinical Hospital №3.
⁷⁴ SBHI of Nizhniy Novgorod region City Outpatient Hospital №1.
⁷⁵ Chita State Medical Academy of Medicine.
⁷⁶ Samara City Polyclinic №3.
⁷⁷ Perm State Medical University named after E.A. Vagner.
⁷⁸ Kazan State Medical Academy - Branch of the Russian Medical Academy of Continuous Professional Education.

PMID: 36286918
DOI: 10.26442/00403660.2022.01.201320

Abstract
in English, Russian

Aim: Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.

Materials and methods: The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.

Clinicaltrials: gov ID NCT04492384.

Results: Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.

Conclusion: Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.

Цель. Изучить влияние различных комбинаций сопутствующих заболеваний, существовавших у пациентов исходно, до инфицирования вирусом SARS-CoV-2, на тяжесть течения и исходы новой коронавирусной инфекции. Материалы и методы. Регистр АКТИВ создан по инициативе Евразийской ассоциации терапевтов. В регистр включены 5808 пациентов: мужчины и женщины с диагнозом COVID-19, находящиеся на лечении в стационаре или получающие лечение на дому. Регистрация регистра: идентификатор ClinicalTrials.gov: NCT04492384. Результаты. Подавляющее большинство пациентов с COVID-19 имеют исходные сопутствующие заболевания (иСЗ). Полиморбидность, оцененная методом простого подсчета иСЗ, является самостоятельным фактором негативного прогноза больных COVID-19. Поиск наиболее часто встречающихся комбинаций из 2, 3, 4 и более СЗ выявил абсолютное доминирование сердечно-сосудистых заболеваний во всех возможных вариантах. Наиболее неблагоприятной при сочетании 2 иСЗ была комбинация, включающая артериальную гипертензию (АГ) и хроническую сердечную недостаточность (ХСН), при сочетании 3 иСЗ комбинация, включающая АГ, ишемическую болезнь сердца (ИБС), ХСН, и при сочетании 4 иСЗ комбинация, включающая АГ, ИБС, ХСН и сахарный диабет. Наличие таких комбинаций приводило к росту риска летального исхода в 3,963, 4,082, 4,215 раза соответственно. Заключение. Полиморбидность, определенная методом простого подсчета заболеваний, может использоваться в реальной практике как фактор риска летальности в остром периоде COVID-19. В состав наиболее часто встречающихся комбинаций из 2, 3, 4 заболеваний у пациентов с COVID-19 входят преимущественно сердечно-сосудистые заболевания (АГ, ИБС, ХСН), сахарный диабет и ожирение. Комбинации этих заболеваний повышают риск летального исхода при COVID-19.

Keywords: ACTIV registry; COVID-19; cardiovascular diseases; diabetes mellitus; disease combinations; polymorbidity.

Publication types

Clinical Study
English Abstract

MeSH terms

Adult
COVID-19* / diagnosis
COVID-19* / epidemiology
Cardiovascular Diseases* / diagnosis
Cardiovascular Diseases* / epidemiology
Cardiovascular Diseases* / etiology
Chronic Disease
Coronary Disease*
Diabetes Mellitus*
Female
Heart Failure*
Humans
Hypertension* / diagnosis
Hypertension* / epidemiology
Male
Noncommunicable Diseases*
Prognosis
Registries
SARS-CoV-2

Associated data

ClinicalTrials.gov/NCT04492384

Abstract in English, Russian

Publication types

MeSH terms

Associated data

Abstract
in English, Russian