Histological Features Associated With Human Mpox Virus Infection in 2022 Outbreak in a Nonendemic Country

Faris Chalali; Marie Merlant; Audrey Truong; Jade Ghosn; Bao-Chau Phung; Bastien Mollo; Ségolène Perrineau; Mayda Rahi; Nadhira Fidouh-Houhou; Valentine Marie Ferré; Florence Brunet-Possenti; Vincent Descamps; Fabrice Bouscarat; Yazdan Yazdanpanah; Lydia Deschamps; Chloé Bertin

doi:10.1093/cid/ciac856

Histological Features Associated With Human Mpox Virus Infection in 2022 Outbreak in a Nonendemic Country

Clin Infect Dis. 2023 Mar 21;76(6):1132-1135. doi: 10.1093/cid/ciac856.

Authors

Faris Chalali¹, Marie Merlant¹, Audrey Truong², Jade Ghosn³, Bao-Chau Phung³, Bastien Mollo³, Ségolène Perrineau³, Mayda Rahi³, Nadhira Fidouh-Houhou⁴, Valentine Marie Ferré⁴, Florence Brunet-Possenti¹, Vincent Descamps¹, Fabrice Bouscarat¹, Yazdan Yazdanpanah³, Lydia Deschamps², Chloé Bertin³

Affiliations

¹ Dermatology Department, AP-HP, Bichat-Claude Bernard Hospital, University of Paris, Paris, France.
² Pathology Department, AP-HP, Bichat-Claude Bernard Hospital, University of Paris, Paris, France.
³ Infectious Diseases Department, AP-HP, Bichat-Claude Bernard Hospital, University of Paris, Paris, France.
⁴ Virology Department, AP-HP, Bichat-Claude Bernard Hospital, University of Paris, INSERM, IAME, UMR 1137, Paris, France.

PMID: 36318605
DOI: 10.1093/cid/ciac856

Abstract

Skin histology of papules and pustules from 5 men having sex with men with mpox infection showed viral intracytoplasmic cytopathic changes, interface dermatitis, marked inflammatory dermic infiltrate including superficial neutrophils and perivascular and periadnexal deep lymphocytes. Histologic description of mpox lesions improves our understanding about clinical presentations and may have some therapeutic implications.

Keywords: histology; imaging; monkeypox; outbreak; poxvirus.

MeSH terms

Blister
Dermatitis*
Disease Outbreaks
Humans
Male
Mpox, Monkeypox*
Neutrophils