Experimental Evaluation of the Effectiveness of Isobornylphenols in the Model of Pathospermia and Their Effect on the Antioxidant-Prooxidant Balance of Male Germ Cells

Bull Exp Biol Med. 2022 Oct;173(6):714-718. doi: 10.1007/s10517-022-05618-9. Epub 2022 Nov 2.

Abstract

We studied the effect of antioxidants dibornol (2,6-diisobornyl-4-methylphenol) and its derivative (4-hydroxymethyl-2,6-diisobornylphenol), members of the alkylated phenols group, on the redox potential of male germ cells and their morphological and functional state in the rat model of pathospermia. Pharmacological effect was observed in animals treated with dibornol. The studied compounds led to the normalization of the antioxidant-prooxidant balance. However, the value of this indicator against the background of treatment with dibornol derivative attested to a shift in the redox balance of cells towards reduction reactions.

Keywords: isobornylphenols; pathospermia; rats; redox potential.

MeSH terms

  • Animals
  • Antioxidants* / metabolism
  • Antioxidants* / pharmacology
  • Antioxidants* / therapeutic use
  • Germ Cells / metabolism
  • Male
  • Oxidation-Reduction
  • Phenols* / pharmacology
  • Phenols* / therapeutic use
  • Rats
  • Reactive Oxygen Species

Substances

  • Antioxidants
  • Reactive Oxygen Species
  • Phenols