Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types; integrating pathway(s) and clinical outcome(s) association

Nada M El-Sheikh; Ahmed I Abulsoud; Eman F Wasfey; Nadia M Hamdy

doi:10.1016/j.prp.2022.154183

Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types; integrating pathway(s) and clinical outcome(s) association

Pathol Res Pract. 2022 Dec:240:154183. doi: 10.1016/j.prp.2022.154183. Epub 2022 Oct 20.

Authors

Nada M El-Sheikh¹, Ahmed I Abulsoud², Eman F Wasfey³, Nadia M Hamdy⁴

Affiliations

¹ Biochemistry Department, Faculty of Pharmacy, Heliopolis University, El Salam City, Cairo 11785, Egypt.
² Biochemistry Department, Faculty of Pharmacy, Heliopolis University, El Salam City, Cairo 11785, Egypt; Biochemistry Department, Faculty of Pharmacy (Boy's branch), Al-Azhar University, Nasr City, Cairo 11884, Egypt.
³ Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
⁴ Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt. Electronic address: [email protected].

PMID: 36327824
DOI: 10.1016/j.prp.2022.154183

Abstract

Long non-coding RNAs (lncRNAs) are becoming more prevalent in the cancer field arena, with functional roles in both oncogenic and onco-suppressive pathways. Despite their widespread aberrant expression in a range of human malignancies, the biological activities of the ncRNAs majority are unknown. All showed the involvement of the lncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1). Since NNT-AS1 influences cellular proliferation, invasion, migration, apoptosis, and metastasis, this lncRNA appears to be linked to deregulating the normal cellular processes driving malignancy. This was observed in breast cancer (BC), gastric cancer (GC), colorectal cancer (CRC), epithelial ovarian cancer (EOC), and hepatocellular carcinoma (HCC). The current narrative non-systematic review will discuss "the significance of lncRNAs in cancer", as well as "lncRNAs future potential application(s) as diagnostic or predictive biomarkers", therefore, comprising an opportunity as treatment target(s). The review will have a special emphasis on lncRNA NNT-AS1.

Keywords: Cancer; Long ncRNA; NNT-AS1; Non-coding RNA; Oncogenes; Tumor suppressor.

Publication types

Review

MeSH terms

Carcinogenesis / genetics
Carcinoma, Hepatocellular* / genetics
Cell Line, Tumor
Cell Movement / genetics
Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms* / genetics
MicroRNAs* / genetics
NADP Transhydrogenases* / genetics
NADP Transhydrogenases* / metabolism
RNA, Antisense / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding
RNA, Antisense
NADP Transhydrogenases
MicroRNAs