Context is key: Modulated protein multivalency in disease

Mikayla Eppert; Benjamin R Sabari

doi:10.1016/j.molcel.2022.10.011

Context is key: Modulated protein multivalency in disease

Mol Cell. 2022 Nov 3;82(21):3965-3967. doi: 10.1016/j.molcel.2022.10.011.

Authors

Mikayla Eppert¹, Benjamin R Sabari²

Affiliations

¹ Laboratory of Nuclear Organization, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Research, Department of Obstetrics and Gynecology, Dallas, TX 75390, USA; Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Laboratory of Nuclear Organization, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Research, Department of Obstetrics and Gynecology, Dallas, TX 75390, USA; Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].

PMID: 36332603
DOI: 10.1016/j.molcel.2022.10.011

Abstract

In this issue of Molecular Cell, Song et al. demonstrate that mutations to the YEATS domain of ENL aberrantly activate gene expression by forming condensates on specific genomic loci. By using diverse experimental approaches, the authors dissect the molecular underpinnings of ENL mutant condensate formation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Protein Domains
Transcription Factors* / metabolism
Transcriptional Elongation Factors* / genetics

Substances

Transcriptional Elongation Factors
Transcription Factors