Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms

Crit Rev Oncol Hematol. 2022 Dec:180:103865. doi: 10.1016/j.critrevonc.2022.103865. Epub 2022 Nov 2.

Abstract

Pancreatic neuroendocrine neoplasms (pNENs) are rare cancers with broad challenges for their management. The main clinical obstacles are the high rate of patients diagnosed at advanced stages, lack of prognostic markers for early detection of disease recurrence in resected patients, significant limitations in identifying those who will benefit from adjuvant therapy, and timely recognition of treatment response. Therefore, the discovery of new prognostic and predictive markers is necessary for patient stratification and clinical management. Liquid biopsy, which has revolutionized the field of clinical oncology, is extremely under-investigated in pNENs. This review highlights its potential and the recent advances in related technologies, as candidates for the delivery of the new tools that can help to refine pNEN diagnosis and to personalize treatment. In addition, the opportunities and limitations of available preclinical research models with regard to biomarker research are discussed in light of pNEN clinical needs.

Keywords: Circulating tumor DNA; Circulating tumor cells; Exosomes; Liquid biopsy; Micro RNA; Pancreatic neuroendocrine neoplasms; Preclinical models.

Publication types

  • Review

MeSH terms

  • Humans
  • Liquid Biopsy
  • Neoplasm Recurrence, Local
  • Neuroendocrine Tumors* / diagnosis
  • Neuroendocrine Tumors* / pathology
  • Neuroendocrine Tumors* / therapy
  • Pancreatic Neoplasms* / diagnosis
  • Pancreatic Neoplasms* / pathology
  • Pancreatic Neoplasms* / therapy
  • Prognosis