Xenobiotic Receptors, a Journey of Rewards

Drug Metab Dispos. 2023 Feb;51(2):207-209. doi: 10.1124/dmd.122.000857. Epub 2022 Nov 9.

Abstract

The xenobiotic nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were discovered or characterized in 1998. PXR and CAR have since been defined as master regulators of xenobiotic responses through their transcriptional regulation of drug-metabolizing enzymes and transporters. This article aims to provide an overview on the discovery of PXR and CAR as xenobiotic receptors.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Carrier Proteins
  • Gene Expression Regulation
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid* / metabolism
  • Reward
  • Xenobiotics

Substances

  • Receptors, Steroid
  • Xenobiotics
  • Receptors, Cytoplasmic and Nuclear
  • Carrier Proteins