A green protocol for the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using modified β-cyclodextrin as a catalyst

Mahdieh Tajbakhsh; Mohammad Reza Naimi-Jamal; Saeed Balalaie; Mohadeseh Rezaeian

doi:10.1038/s41598-022-23814-5

A green protocol for the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using modified β-cyclodextrin as a catalyst

Sci Rep. 2022 Nov 9;12(1):19106. doi: 10.1038/s41598-022-23814-5.

Authors

Mahdieh Tajbakhsh¹, Mohammad Reza Naimi-Jamal², Saeed Balalaie³, Mohadeseh Rezaeian¹

Affiliations

¹ Research Laboratory of Green Organic Synthesis & Polymers, Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran.
² Research Laboratory of Green Organic Synthesis & Polymers, Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran. [email protected].
³ Peptide Chemistry Research Institute, K.N Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran.

Abstract

This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst. The architecture of this catalyst was characterized by different analytical techniques such as Fourier transform infrared spectroscopy, Thermogravimetric analysis, X-ray diffraction, Field emission scanning electron microscopy, and Energy-dispersive X-ray spectroscopy. The catalyst showed remarkable reusability even after 7 consecutive runs.

MeSH terms

Catalysis
Isoxazoles*
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
beta-Cyclodextrins* / chemistry

Substances

Isoxazoles
beta-Cyclodextrins