Structure revision and chemical synthesis of ligandrol's main bishydroxylated long-term metabolic marker

Org Biomol Chem. 2022 Nov 30;20(46):9112-9116. doi: 10.1039/d2ob01907h.

Abstract

Although the main bishydroxylated long-term metabolite of the WADA-banned anabolic agent ligandrol (LGD-4033) is an important metabolic marker, it is not readily available in sufficient quantities to facilitate the development and validation of related analytical protocols or sensors. A chemically more robust structure was postulated as an alternative to the one previously established. The NMR spectra of the synthesized material and its LC-HRMS comparison with a relevant metabolic sample support the proposed structural revision.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Substance Abuse Detection* / methods
  • Tandem Mass Spectrometry* / methods