Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants

Virol Sin. 2022 Dec;37(6):938-941. doi: 10.1016/j.virs.2022.11.003. Epub 2022 Nov 8.

Abstract

  1. -

    Deletion of residues 156–157 warps the neighboring beta-sheet and leads NTD and RBD to shift.

  2. -

    T859N stabilizes the packing of the 630 loop motif to make RBD standing transition more difficult.

  3. -

    The overall structures of the closed state S complex from different variants resemble each other.

  4. -

    Mutations in FPPR may affect the overall structure of the trimeric spike protein.

Publication types

  • Letter

MeSH terms

  • COVID-19*
  • Humans
  • Mutation
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus

Substances

  • spike protein, SARS-CoV-2
  • Spike Glycoprotein, Coronavirus