Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA-reactive carcinogens

ALTEX. 2023;40(2):341-349. doi: 10.14573/altex.2210111. Epub 2022 Nov 11.

Authors

Sylvia E Escher¹, Susan P Felter², Heli Hollnagel³, Alan R Boobis⁴, Chihae Yang⁵, James Rathman⁵, Mark T D Cronin⁶, Monika Batke¹

Affiliations

¹ Fraunhofer ITEM, Hannover, Germany.
² Procter & Gamble, Central Product Safety, Mason, OH, USA.
³ Dow Europe GmbH, Horgen, Switzerland.
⁴ Liverpool John MooresUniversity, Liverpool, UK.
⁵ Molecular Networks-Altamira, Nürnberg, Germany.
⁶ National Heart and Lung Institute, Imperial College London, London, UK.

PMID: 36383628
DOI: 10.14573/altex.2210111

No abstract available

Keywords: DNA reactive carcinogens; TTC; bench mark dose; carcinogen database; threshold derivation.

Publication types

Editorial

MeSH terms

Animal Testing Alternatives*
Animals
Carcinogens* / toxicity
Databases, Factual
No-Observed-Adverse-Effect Level
Risk Assessment

Substances

Carcinogens