Biological Stratification of Invasive and Advanced Urothelial Carcinoma

Moritz J Reike; Alberto Contreras-Sanz; Peter C Black

doi:10.1016/j.ucl.2022.09.007

Biological Stratification of Invasive and Advanced Urothelial Carcinoma

Urol Clin North Am. 2023 Feb;50(1):69-80. doi: 10.1016/j.ucl.2022.09.007.

Authors

Moritz J Reike¹, Alberto Contreras-Sanz², Peter C Black³

Affiliations

¹ Department of Urologic Sciences, University of British Columbia, Gordon & Leslie Diamond Health Care Centre, Level 6, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada; Department of Urology, Marien Hospital Herne, Ruhr-University Bochum, Hölkeskampring 40, 44625 Herne, Germany.
² Department of Urologic Sciences, University of British Columbia, Gordon & Leslie Diamond Health Care Centre, Level 6, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada.
³ Department of Urologic Sciences, University of British Columbia, Gordon & Leslie Diamond Health Care Centre, Level 6, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada. Electronic address: [email protected].

PMID: 36424084
DOI: 10.1016/j.ucl.2022.09.007

Abstract

Muscle-invasive urothelial carcinoma (UC) of the bladder remains a highly lethal malignancy. In this review the authors explore the underlying biology associated with the evolution from non-muscle-invasive UC to muscle-invasive and metastatic UC, with a special focus on the molecular stratification of UC and the potential of this stratification to be used for treatment selection.

Keywords: Bladder cancer; Classifier; Genetic mutation; Molecular subtyping.

Publication types

Review

MeSH terms

Carcinoma, Transitional Cell* / pathology
Humans
Urinary Bladder Neoplasms* / pathology