Greater genetic diversity is needed in human pluripotent stem cell models

Sulagna Ghosh; Ralda Nehme; Lindy E Barrett

doi:10.1038/s41467-022-34940-z

Greater genetic diversity is needed in human pluripotent stem cell models

Nat Commun. 2022 Nov 26;13(1):7301. doi: 10.1038/s41467-022-34940-z.

Authors

Sulagna Ghosh^{1

2}, Ralda Nehme^{3

4}, Lindy E Barrett^{5

6}

Affiliations

¹ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. [email protected].
² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA. [email protected].
³ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. [email protected].
⁴ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA. [email protected].
⁵ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. [email protected].
⁶ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA. [email protected].

Abstract

While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.

Greater genetic diversity is needed in human pluripotent stem cell models

Authors

Affiliations

Abstract

Publication types

MeSH terms

Grants and funding