A Malignant Glomus Tumor of the Liver Harboring MIR143-NOTCH2 Rearrangement: From Diagnosis to Management

Ruoyu Miao; Marilyn M Bui; Christine Walko; John E Mullinax; Andrew S Brohl

doi:10.7759/cureus.30718

A Malignant Glomus Tumor of the Liver Harboring MIR143-NOTCH2 Rearrangement: From Diagnosis to Management

Cureus. 2022 Oct 26;14(10):e30718. doi: 10.7759/cureus.30718. eCollection 2022 Oct.

Authors

Ruoyu Miao¹, Marilyn M Bui², Christine Walko³, John E Mullinax⁴, Andrew S Brohl⁴

Affiliations

¹ Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA.
² Department of Pathology, Moffitt Cancer Center, Tampa, USA.
³ Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, USA.
⁴ Department of Sarcoma, Moffitt Cancer Center, Tampa, USA.

Abstract

A primary malignant glomus tumor of the liver is extremely rare and diagnostically challenging. We present an exceptional case of such with a diagnosis confirmed by MIR143-NOTCH2 rearrangement. The case was successfully managed with neoadjuvant chemotherapy followed by surgery. This report highlights the utilization of molecular analysis to aid in the diagnosis of rare soft tissue malignancies and supports a multimodality approach to the treatment of large, high-grade malignant glomus tumors.

Keywords: chemotherapy; gene fusion; malignant glomus tumor; next generation sequencing; notch.

Publication types

Case Reports