Disturbance of cellular calcium homeostasis plays a pivotal role in glyphosate-based herbicide-induced oxidative stress

Diovana Gelati de Batista; Edivania Gelati de Batista; Antônio Azambuja Miragem; Mirna Stela Ludwig; Thiago Gomes Heck

doi:10.1007/s11356-022-24361-2

Disturbance of cellular calcium homeostasis plays a pivotal role in glyphosate-based herbicide-induced oxidative stress

Environ Sci Pollut Res Int. 2023 Jan;30(4):9082-9102. doi: 10.1007/s11356-022-24361-2. Epub 2022 Nov 28.

Authors

Diovana Gelati de Batista^{1

2

3

4}, Edivania Gelati de Batista⁵, Antônio Azambuja Miragem⁵, Mirna Stela Ludwig^{6

7}, Thiago Gomes Heck^{6

7

8}

Affiliations

¹ Research Group in Physiology, Regional University of Northwestern Rio Grande Do Sul State, Rio Grande Do Sul State, Ijuí, Brazil. [email protected].
² Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande Do Sul State, Rio Grande Do Sul State, Ijuí, Brazil. [email protected].
³ Research Group in Cell Stress Response, Federal Institute of Education, Science and Technology Farroupilha, Rio Grande Do Sul State, Santa Rosa, Brazil. [email protected].
⁴ Postgraduate Program in Mathematical and Computational Modeling, Regional University of Northwestern Rio Grande Do Sul State, Rio Grande Do Sul State, Ijuí, Brazil. [email protected].
⁵ Research Group in Cell Stress Response, Federal Institute of Education, Science and Technology Farroupilha, Rio Grande Do Sul State, Santa Rosa, Brazil.
⁶ Research Group in Physiology, Regional University of Northwestern Rio Grande Do Sul State, Rio Grande Do Sul State, Ijuí, Brazil.
⁷ Postgraduate Program in Integral Attention to Health, Regional University of Northwestern Rio Grande Do Sul State, Rio Grande Do Sul State, Ijuí, Brazil.
⁸ Postgraduate Program in Mathematical and Computational Modeling, Regional University of Northwestern Rio Grande Do Sul State, Rio Grande Do Sul State, Ijuí, Brazil.

PMID: 36441326
DOI: 10.1007/s11356-022-24361-2

Abstract

Glyphosate-based herbicides (GBHs) are the most worldwide used pesticides. The wide application of GBHs contaminates the soil and, consequently, water and food resources reaching human consumption. GBHs induce oxidative stress in non-target organisms, leading to a pro-inflammatory and pro-apoptotic cellular status, promoting tissue dysfunction and, thus, metabolic and neurobehavioral changes. This review presents evidence of oxidative damage induced by GBHs and the mechanism of cell damage and health consequences. To summarize, exposure to GBHs may induce disorders in calcium homeostasis related to the activation of ion channels. Also, alterations in pathways related to redox state regulation must have a primordial role in oxidative stress caused by GBHs.

Keywords: Calcium; Cell death; Glyphosate; Inflammation; Pesticide; Reactive oxygen species; Toxicity.

Publication types

Review

MeSH terms

Calcium*
Glyphosate
Herbicides* / toxicity
Homeostasis
Humans
Oxidative Stress

Substances

Calcium
Herbicides

Grants and funding

00000001/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior