Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Fuxue Zhang; Bozhang Xia; Jiabei Sun; Yufei Wang; Jinjin Wang; Fengfei Xu; Junge Chen; Mei Lu; Xin Yao; Peter Timashev; Yuanyuan Zhang; Meiwan Chen; Jing Che; Fangzhou Li; Xing-Jie Liang

doi:10.34133/2022/9808429

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Research (Wash D C). 2022 Oct 31:2022:9808429. doi: 10.34133/2022/9808429. eCollection 2022.

Authors

Fuxue Zhang^{1

2}, Bozhang Xia^{1

3}, Jiabei Sun⁴, Yufei Wang^{1

3}, Jinjin Wang^{1

3}, Fengfei Xu^{1

3}, Junge Chen^{1

5}, Mei Lu^{1

6}, Xin Yao⁷, Peter Timashev⁸, Yuanyuan Zhang⁸, Meiwan Chen⁹, Jing Che³, Fangzhou Li^{1

3}, Xing-Jie Liang^{1

3}

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China.
² Sino-Danish Center for Education and Research, Sino-Danish College of University of Chinese Academy of Sciences, Beijing 100049, China.
³ School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
⁴ China National Institutes for Food and Drug Control, Beijing 102629, China.
⁵ Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing 100083, China.
⁶ Advanced Research Institute of Multidisciplinary Science, School of Life Science, School of Medical Technology (Institute of Engineering Medicine), Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China.
⁷ School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
⁸ Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia.
⁹ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.

Abstract

Intelligent drug delivery system based on "stimulus-response" mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

Publication types

Review