Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors

Xiaomin Liang; Yuding Wei; Xingzi Hou; Qiang Guo; Hong Liang; Kewu Zeng; Pengfei Tu; Qingying Zhang

doi:10.1016/j.phytochem.2022.113530

Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors

Phytochemistry. 2023 Feb:206:113530. doi: 10.1016/j.phytochem.2022.113530. Epub 2022 Nov 29.

Authors

Xiaomin Liang¹, Yuding Wei¹, Xingzi Hou¹, Qiang Guo², Hong Liang¹, Kewu Zeng¹, Pengfei Tu¹, Qingying Zhang³

Affiliations

¹ State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
² School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
³ State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China. Electronic address: [email protected].

PMID: 36455653
DOI: 10.1016/j.phytochem.2022.113530

Abstract

Seven undescribed triterpenoids were obtained from the ethanol extract of the dried stems of Uncaria macrophylla Wall. (Rubiaceae).All of the isolates were urs-28-oic acid or olean-28-oic acid skeletons, including three triterpenoids with rare 3β,23-(1R-4-hydroxy-butyl-1,1-dioxy) or 23-(2R-tetrahydrofuran-2-oxy) substituents. Five triterpenoids showed promising inhibitory activity against erastin-induced ferroptosis in PC12 cells, while 3β,6α,23-trihydroxy-olean-12-en-28-oic acid was the most significant inhibitor to resist ferroptosis by activating the Nrf2/SLC7A11/GPx4 axis with an EC₅₀ value of 4.2 ± 0.7 μM.

Keywords: Ferroptosis; Neuroprotective effect; Rubiaceae; Triterpenoids; Uncaria macrophylla.

MeSH terms

Ethanol
Ferroptosis*
Triterpenes* / pharmacology
Uncaria*

Substances

Triterpenes
Ethanol