Drug-induced enterocolitis syndrome: A rare, severe, non-IgE-mediated immediate drug allergy. Case report and literature review

C Eyraud; P Biermé; M Adam; C Braun

doi:10.1016/j.arcped.2022.11.007

Drug-induced enterocolitis syndrome: A rare, severe, non-IgE-mediated immediate drug allergy. Case report and literature review

Arch Pediatr. 2023 Jan;30(1):67-70. doi: 10.1016/j.arcped.2022.11.007. Epub 2022 Nov 30.

Authors

C Eyraud¹, P Biermé¹, M Adam¹, C Braun²

Affiliations

¹ Service de Pédiatrie, Pneumologie, Allergologie et Mucoviscidose, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
² Service de Pédiatrie, Pneumologie, Allergologie et Mucoviscidose, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR 5308, UCBL1, ENS de Lyon, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France. Electronic address: [email protected].

PMID: 36462992
DOI: 10.1016/j.arcped.2022.11.007

Abstract

We report the case of a 4-year-old child who presented with vomiting, abdominal pain, and intense pallor 2 h after amoxicillin ingestion. An IgE-mediated reaction was suspected at first, which was finally diagnosed as a drug-induced enterocolitis syndrome. In this rare and poorly described non-IgE-mediated drug allergy, adrenaline is not effective. This diagnostic challenge must be known in order to administer adequate treatment, i.e., antiemetic drugs (ondansetron) and fluid challenge.

Keywords: Drug hypersensitivity reaction; Drug-induced enterocolitis syndrome; Food protein-induced enterocolitis syndrome; Non-IgE-mediated allergy.

Publication types

Review
Case Reports

MeSH terms

Amoxicillin
Child, Preschool
Dietary Proteins
Drug Hypersensitivity*
Enterocolitis* / chemically induced
Enterocolitis* / diagnosis
Food Hypersensitivity* / diagnosis
Humans
Hypersensitivity, Immediate*
Infant
Syndrome
Vomiting / chemically induced

Substances

Amoxicillin
Dietary Proteins