Herein, a concise and robust approach for the highly efficient assembly of [60]fullerene-fused tricyclic scaffolds has been developed through a palladium-catalyzed cascade [2 + 2 + 2] annulation process. Diverse tricyclic scaffolds incorporating various ring sizes (6-19 membered) and types (carbocycles and N- and O-heterocycles) can be expediently constructed in a single-step transformation.