Electrochemical Detection of Dopamine using a Phenyl Carboxylic Acid-Functionalized Electrode Made by Electrochemical Reduction of a Diazonium Salt

Saima Anjum; Baohua Lou; Amiza Tahir; Aziz-Ur-Rehman; M Rehan H Shah Gilani; Guobao Xu

doi:10.1002/open.202200233

Electrochemical Detection of Dopamine using a Phenyl Carboxylic Acid-Functionalized Electrode Made by Electrochemical Reduction of a Diazonium Salt

ChemistryOpen. 2022 Dec;11(12):e202200233. doi: 10.1002/open.202200233.

Authors

Saima Anjum^{1

2

3}, Baohua Lou¹, Amiza Tahir³, Aziz-Ur-Rehman^{1

2

4}, M Rehan H Shah Gilani⁵, Guobao Xu^{1

6}

Affiliations

¹ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P.R. China.
² Chinese Academy of Sciences, University of Chinese Academy of Sciences, No. 19A Yuquanlu, Beijing, 100049, P.R. China.
³ Department of Chemistry, Govt. Sadiq College Women University, Bahawalpur, Pakistan.
⁴ Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
⁵ Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
⁶ University of Science and Technology of China, Anhui, 230026, P.R. China.

Abstract

A glassy carbon electrode (GCE) has been modified by an in situ electrochemical reduction of an aryldiazonium salt generated from the reaction of 4-aminobenzoic acid and sodium nitrite in acidic ethanolic solution. The as-prepared phenyl carboxylic acid-modified glassy carbon electrode has been, for the first time, used for the electrochemical determination of dopamine. Under optimal experimental parameters, outstanding electrocatalytic activity, high sensitivity at a LOD of 5.6×10^-9 m, and broad linearity of 0.1 to 1000 μm were obtained. The crafted electrochemical platform demonstrated excellent stability, specificity, and anti-interference capability towards the sensing of dopamine.

Keywords: ascorbic acid; chemically modified electrode; diazonium; dopamine analysis; electrochemical sensing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon
Carboxylic Acids*
Dopamine*

Substances

Dopamine
Carboxylic Acids
Carbon