Editorial: Cerebral oxygen supply and demand in sickle cell disease: Evidence of local ischemia despite global hyperemia

Meher R Juttukonda; Lena Vaclavu; Fenella J Kirkham; Melanie E Fields; Adam M Bush

doi:10.3389/fphys.2022.1079889

Editorial: Cerebral oxygen supply and demand in sickle cell disease: Evidence of local ischemia despite global hyperemia

Front Physiol. 2022 Nov 21:13:1079889. doi: 10.3389/fphys.2022.1079889. eCollection 2022.

Authors

Meher R Juttukonda^{1

2}, Lena Vaclavu³, Fenella J Kirkham⁴, Melanie E Fields⁵, Adam M Bush⁶

Affiliations

¹ Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
² Department of Radiology, Harvard Medical School, Boston, MA, United States.
³ C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.
⁴ Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
⁵ Division of Pediatric Hematology/Oncology, Washington University in St. Louis, Saint Louis, MO, United States.
⁶ Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX, United States.

No abstract available

Keywords: blood flow; borderzone (watershed); brain; cerebrovascular reactivity; ischemia; magnetic resonance imaging; oxygen extraction; sickle cell disease.

Publication types

Editorial