Pulmonary hypertension due to high cardiac output

Kanza N Qaiser; Sandeep Sahay; Adriano R Tonelli

doi:10.1016/j.rmed.2022.107034

Pulmonary hypertension due to high cardiac output

Respir Med. 2023 Jan:206:107034. doi: 10.1016/j.rmed.2022.107034. Epub 2022 Oct 31.

Authors

Kanza N Qaiser¹, Sandeep Sahay², Adriano R Tonelli³

Affiliations

¹ Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH, USA. Electronic address: [email protected].
² Houston Methodist Lung Center, Division of Pulmonary, Critical Care & Sleep Medicine, Houston Methodist Hospital, Houston, TX, USA. Electronic address: [email protected].
³ Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: [email protected].

PMID: 36511685
DOI: 10.1016/j.rmed.2022.107034

Abstract

Pulmonary hypertension (PH) is usually associated with a normal or decreased cardiac output (CO). Less commonly, PH can occur in the context of a hyperdynamic circulation, characterized by high CO (>8 L/min) and/or cardiac index ≥4 L/min/m² in the setting of a decreased systemic vascular resistance. PH due to high CO can occur due to multiple conditions and in general remains understudied. In this review article we describe the pathophysiology, etiology, diagnosis, hemodynamic characteristics, and management of PH in the setting of high CO. It is important to recognize this distinct entity as PH tends to improve with treatment of the underlying etiology and PH specific therapies may worsen the hemodynamic state.

Keywords: High cardiac output; Hyperdynamic state; Pulmonary hypertension.

Publication types

Review

MeSH terms

Cardiac Output
Cardiac Output, High*
Hemodynamics / physiology
Humans
Hypertension, Pulmonary* / diagnosis
Hypertension, Pulmonary* / etiology
Hypertension, Pulmonary* / therapy
Vascular Resistance / physiology