Good intentions gone wrong: The B cell block to epithelial repair

Emilie K Grasset; Theresa Alenghat

doi:10.1016/j.immuni.2022.11.011

Good intentions gone wrong: The B cell block to epithelial repair

Immunity. 2022 Dec 13;55(12):2222-2224. doi: 10.1016/j.immuni.2022.11.011.

Authors

Emilie K Grasset¹, Theresa Alenghat²

Affiliations

¹ Department of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Weill Cornell Medicine, Cornell University, New York, NY, USA.
² Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: [email protected].

Abstract

Cellular dynamics that influence mucosal healing are not well understood. In this issue of Immunity, Frede, Czarnewski, Monasterio et al. find that B cells accumulate in the colon following intestinal injury. These B cells impair epithelial repair by hindering local stromal-epithelial interactions.

Good intentions gone wrong: The B cell block to epithelial repair

Authors

Affiliations

Abstract

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Grants and funding