Abstract
The results of a pharmacological investigation on a series of meta-substituted benzyltrimethylammonium salts possessing an antimuscarinic activity are reported. Correlative analysis shows that the pharmacodynamic activity is a function of the hydrophobic-lipophilic parameter associated with the substituent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chemical Phenomena
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Chemistry
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Chromatography, High Pressure Liquid
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Parasympatholytics / chemical synthesis*
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Quaternary Ammonium Compounds / chemical synthesis*
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Quaternary Ammonium Compounds / pharmacology
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Rats
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Structure-Activity Relationship
Substances
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Parasympatholytics
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Quaternary Ammonium Compounds
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benzyltrimethylammonium