Assessing critical temperature dose areas in the kidney by magnetic resonance imaging thermometry in an ex vivo Holmium:YAG laser lithotripsy model

Purpose: We aimed to assess critical temperature areas in the kidney parenchyma using magnetic resonance thermometry (MRT) in an ex vivo Holmium:YAG laser lithotripsy model.

Methods: Thermal effects of Ho:YAG laser irradiation of 14 W and 30 W were investigated in the calyx and renal pelvis of an ex vivo kidney with different laser application times (t_L) followed by a delay time (t_D) of t_L/t_D = 5/5 s, 5/10 s, 10/5 s, 10/10 s, and 20/0 s, with irrigation rates of 10, 30, 50, 70, and 100 ml/min. Using MRT, the size of the area was determined in which the thermal dose as measured by the Cumulative Equivalent Minutes (CEM₄₃) method exceeded a value of 120 min.

Results: In the calyx, CEM₄₃ never exceeded 120 min for flow rates ≥ 70 ml/min at 14 W, and longer t_L (10 s vs. 5 s) lead to exponentially lower thermal affection of tissue (3.6 vs. 21.9 mm²). Similarly at 30 W and ≥ 70 ml/min CEM₄₃ was below 120 min. Interestingly, at irrigation rates of 10 ml/min, t_L = 10 s and t_D = 10 s CEM₄₃ were observed > 120 min in an area of 84.4 mm² and 49.1 mm² at t_D = 5 s. Here, t_L = 5 s revealed relevant thermal affection of 29.1 mm² at 10 ml/min.

Conclusion: We demonstrate that critical temperature dose areas in the kidney parenchyma were associated with high laser power and application times, a low irrigation rate, and anatomical volume of the targeted calyx.