Childhood Guillain-Barre syndrome in the SARS-CoV-2 era: Is there any causative relation?

Elham Pourbakhtyaran; Morteza Heidari; Masood Ghahvechi Akbari; Mahmoud Mohammadi; Reza Shervin Badv; Gholamreza Zamani; Ali Reza Tavasoli; Zahra Rezaei; Setareh Mamishi; Elmira Haji Esmaeil Memar; Seyyed Mohammad Mahdi Hosseiny; Homa Ghabeli; Roya Haghighi; Mahmoud Reza Ashrafi

doi:10.1002/ccr3.6772

Childhood Guillain-Barre syndrome in the SARS-CoV-2 era: Is there any causative relation?

Clin Case Rep. 2022 Dec 20;10(12):e6772. doi: 10.1002/ccr3.6772. eCollection 2022 Dec.

Authors

Elham Pourbakhtyaran¹, Morteza Heidari^{1

2}, Masood Ghahvechi Akbari³, Mahmoud Mohammadi¹, Reza Shervin Badv¹, Gholamreza Zamani¹, Ali Reza Tavasoli^{1

2}, Zahra Rezaei¹, Setareh Mamishi⁴, Elmira Haji Esmaeil Memar⁵, Seyyed Mohammad Mahdi Hosseiny⁶, Homa Ghabeli¹, Roya Haghighi¹, Mahmoud Reza Ashrafi¹

Affiliations

¹ Department of Pediatric Neurology, Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran.
² Myelin Disorders Clinic, Pediatric Neurology Division, Children's Medical Center, Pediatrics Center of Excellence Tehran University of Medical Sciences Tehran Iran.
³ Department of Physical Medicine and Rehabilitation, Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran.
⁴ Pediatric Infectious Disease Research Center Tehran University of Medical Sciences Tehran Iran.
⁵ Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran.
⁶ Department of Pediatric Neurology, School of Medicine Hamadan University of medical sciences Hamadan Iran.

Abstract

We reported an association between SARS-CoV-2 infection and Guillain-Barre syndrome (GBS). From 37 patients with GBS, previous SARS-CoV-2 clinical clues, including fever, cough, and diarrhea, were recorded in 18 patients. Among them, SARS-CoV-2 IgG was detected in seven patients, considered confirmed as cases. SARS-CoV-2 PCR was positive in just one patient. Although we found no increase in patient recruitment during the pandemic compared to previous years, our study indicated that SARS-CoV-2 is associated with poorer outcomes regarding GBS disability scale and hospital stay.

Keywords: Guillain–Barre syndrome; SARS‐CoV‐2; pediatric.

Publication types

Case Reports