Structurally diverse sulphur-containing amides from Glycosmis craibii with their potential antiproliferative activities

Shou-Yuan Wu; Zi-Ming Chen; Qi Zhou; Guo-Ling Huang; Zhong-Liu Zhou; Meng Bai

doi:10.1016/j.fitote.2022.105418

Structurally diverse sulphur-containing amides from Glycosmis craibii with their potential antiproliferative activities

Fitoterapia. 2023 Mar:165:105418. doi: 10.1016/j.fitote.2022.105418. Epub 2022 Dec 29.

Authors

Shou-Yuan Wu¹, Zi-Ming Chen¹, Qi Zhou², Guo-Ling Huang¹, Zhong-Liu Zhou¹, Meng Bai³

Affiliations

¹ Western Guangdong Characteristic Biology and Medicine Engineering and Research Center, School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524000, China.
² Western Guangdong Characteristic Biology and Medicine Engineering and Research Center, School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524000, China; Institute of Natural Medicine and Health Products, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, School of Advanced Study, Taizhou University, Taizhou 318000, China. Electronic address: [email protected].
³ Western Guangdong Characteristic Biology and Medicine Engineering and Research Center, School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524000, China; Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China. Electronic address: [email protected].

PMID: 36587747
DOI: 10.1016/j.fitote.2022.105418

Abstract

Fourteen new sulphur-containing amides, glycocramides A-N (1-14), as well as nine known analogues (15-23) were isolated and characterized from Glycosmis craibii Tanaka. The chemical structures of new sulphur-containing amides 1-14 were ambiguously elucidated by extensive spectroscopic methods, while the known compounds 15-23 were identified by the comparison of their experimental spectral data with those described data in the literatures. The antiproliferative effects of all isolated sulphur-containing amides were evaluated in vitro. As a result, part of sulphur-containing amides showed remarkable inhibitory effects against MGC-803 cell line with IC₅₀ values ranging from 13.12 ± 0.10 to 20.03 ± 0.13 μM. These research results suggest that the sulphur-containing amides are potentially to be developed as a new natural anti-tumor drugs.

Keywords: Antiproliferative activities; Glycosmis craibii; Rutaceae; Sulphur-containing amides.

MeSH terms

Amides* / chemistry
Amides* / pharmacology
Cell Line, Tumor
Molecular Structure
Plant Extracts / chemistry
Rutaceae* / chemistry
Sulfur

Substances

Amides
Sulfur
Plant Extracts