Effects of methylphenidate and d-amphetamine on timing in the rat

Pharmacol Biochem Behav. 1987 Jul;27(3):513-5. doi: 10.1016/0091-3057(87)90356-x.

Abstract

Rats were trained to press a lever for food pellets provided according to a fixed interval 60-sec schedule of reinforcement. Probe trials (peak trials) assessed responding over two-min periods with no pellet delivered. The low rates of responding found early and late in probe trials were increased by methylphenidate and 1.0 mg/kg d-amphetamine (rate-dependent effect). Further, the mean time of responding (peak time) was shortened for both drugs (timing effect).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Conditioning, Operant / drug effects*
  • Dextroamphetamine / pharmacology*
  • Male
  • Methylphenidate / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Reaction Time / drug effects
  • Time Perception / drug effects*

Substances

  • Methylphenidate
  • Dextroamphetamine