A pilot study of same-day MRI-only simulation and treatment with MR-guided adaptive palliative radiotherapy (MAP-RT)

Joshua P Schiff; Borna Maraghechi; Re-I Chin; Alex Price; Eric Laugeman; Souman Rudra; Casey Hatscher; Matthew B Spraker; Shahed N Badiyan; Lauren E Henke; Olga Green; Hyun Kim

doi:10.1016/j.ctro.2022.100561

A pilot study of same-day MRI-only simulation and treatment with MR-guided adaptive palliative radiotherapy (MAP-RT)

Clin Transl Radiat Oncol. 2022 Dec 15:39:100561. doi: 10.1016/j.ctro.2022.100561. eCollection 2023 Mar.

Authors

Affiliations

¹ Washington University School of Medicine in St. Louis, Department of Radiation Oncology, St. Louis, MO, USA.
² Emory University School of Medicine, Department of Radiation Oncology, Atlanta, GA, USA.
³ Varian Medical Systems, Palo Alto, CA, USA.

Abstract

We conducted a prospective pilot study evaluating the feasibility of same day MRI-only simulation and treatment with MRI-guided adaptive palliative radiotherapy (MAP-RT) for urgent palliative indications (NCT#03824366). All (16/16) patients were able to complete 99% of their first on-table attempted fractions, and no grades 3-5 toxicities occurred.

Keywords: Adaptive radiation; CT Simulation-Free; Electron density calculations; MRI; Palliative radiation; Physics; Treatment.