Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice

Qiling Ruan; Yihan Chen; Jiahui Wen; Yinghui Qiu; Yajun Huang; Yi Zhang; Mohamed A Farag; Chao Zhao

doi:10.1016/j.foodchem.2022.135287

Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice

Food Chem. 2023 May 30:409:135287. doi: 10.1016/j.foodchem.2022.135287. Epub 2022 Dec 23.

Authors

Qiling Ruan¹, Yihan Chen¹, Jiahui Wen¹, Yinghui Qiu¹, Yajun Huang¹, Yi Zhang¹, Mohamed A Farag², Chao Zhao³

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.
² Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
³ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, China. Electronic address: [email protected].

PMID: 36603475
DOI: 10.1016/j.foodchem.2022.135287

Abstract

In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice. The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level. Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction. Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes. These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.

Keywords: Aging; Intestinal flora; Type 2 diabetics; Ulva lactuca polysaccharide.

MeSH terms

Animals
Blood Glucose / metabolism
Diabetes Mellitus, Experimental* / drug therapy
Diabetes Mellitus, Experimental* / genetics
Diabetes Mellitus, Type 2* / drug therapy
Diabetes Mellitus, Type 2* / genetics
Diabetes Mellitus, Type 2* / metabolism
Gastrointestinal Microbiome*
Hypoglycemic Agents / pharmacology
Insulins* / pharmacology
Mice
Polysaccharides / pharmacology
Ulva* / genetics
Ulva* / metabolism

Substances

Blood Glucose
Polysaccharides
Hypoglycemic Agents
Insulins