A young woman with persistent sore throat, Epstein-Barr virus, lymphadenopathy, and aberrant CD4 + CD7- T-cells

Mariam Goubran; Eric McGinnis; Ryan J Stubbins; Hamish Nicolson; Persia Pourshahnazari; Sara Belga; Hayley Merkeley; Thomas J Nevill; Luke Y C Chen

doi:10.1002/ajh.26838

A young woman with persistent sore throat, Epstein-Barr virus, lymphadenopathy, and aberrant CD4 + CD7- T-cells

Am J Hematol. 2023 May;98(5):824-829. doi: 10.1002/ajh.26838. Epub 2023 Jan 18.

Authors

Mariam Goubran¹, Eric McGinnis², Ryan J Stubbins³, Hamish Nicolson², Persia Pourshahnazari⁴, Sara Belga⁵, Hayley Merkeley⁶, Thomas J Nevill³, Luke Y C Chen⁶

Affiliations

¹ Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
² Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
³ Leukemia/Bone Marrow Transplant Program of British Columbia and Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
⁴ Division of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
⁵ Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
⁶ Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

PMID: 36606704
DOI: 10.1002/ajh.26838

Abstract

A young woman with persistent EBV viremia and lymphocytosis had an abnormal CD4- T cell population with aberrant loss of CD7. She had a diagnosis of chronic active EBV (CAEBV), a lymphoproliferative disorder for which she ultimately required allogeneic hematopoietic stem cell transplantation.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD7 / immunology
CD4 Antigens / immunology
Epstein-Barr Virus Infections* / complications
Female
Herpesvirus 4, Human
Humans
Lymphadenopathy*
Lymphoproliferative Disorders* / etiology
Pharyngitis*
T-Lymphocytes

Substances

CD4 Antigens
Antigens, CD7