Tuning Peptide-Based Hydrogels: Co-Assembly with Composites Driving the Highway to Technological Applications

Int J Mol Sci. 2022 Dec 22;24(1):186. doi: 10.3390/ijms24010186.

Abstract

Self-assembled peptide-based gels provide several advantages for technological applications. Recently, the co-assembly of gelators has been a strategy to modulate and tune gel properties and even implement stimuli-responsiveness. However, it still comprises limitations regarding the required library of compounds and outcoming properties. Hence, efforts have been made to combine peptide-based gels and (in)organic composites (e.g., magnetic nanoparticles, metal nanoparticles, liposomes, graphene, silica, clay, titanium dioxide, cadmium sulfide) to endow stimuli-responsive materials and achieve suitable properties in several fields ranging from optoelectronics to biomedical. Herein, we discuss the recent developments with composite peptide-based gels including the fabrication, tunability of gels' properties, and challenges on (bio)technological applications.

Keywords: clay nanoparticles; graphene; hydrogels; liposomes; magnetic nanoparticles; metal nanoparticles; peptide-based composite hydrogels; peptides.

Publication types

  • Review

MeSH terms

  • Hydrogels*
  • Liposomes
  • Peptides
  • Stimuli Responsive Polymers*

Substances

  • Hydrogels
  • Peptides
  • Stimuli Responsive Polymers
  • Liposomes