Covalent Rescue of Mutant p53

David P Lane; Chandra S Verma

doi:10.1158/2159-8290.CD-22-1212

Covalent Rescue of Mutant p53

Cancer Discov. 2023 Jan 9;13(1):14-16. doi: 10.1158/2159-8290.CD-22-1212.

Authors

David P Lane¹, Chandra S Verma^{2

3

4}

Affiliations

¹ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet - Biomedicum, Solnavägen 9, Solna, Sweden.
² Bioinformatics Institute (A*STAR), Singapore.
³ School of Biological Sciences, Nanyang Technological University, Singapore.
⁴ Department of Biological Sciences, National University of Singapore, Singapore.

PMID: 36620883
DOI: 10.1158/2159-8290.CD-22-1212

Abstract

p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3).

Publication types

Editorial
Comment

MeSH terms

Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Tumor Suppressor Protein p53* / genetics
Tumor Suppressor Protein p53* / metabolism

Substances

Tumor Suppressor Protein p53