Tuberculosis: The tug of war between pathogen and inflammasome

Filip Van Hauwermeiren; Mohamed Lamkanfi

doi:10.1016/j.cub.2022.11.025

Tuberculosis: The tug of war between pathogen and inflammasome

Curr Biol. 2023 Jan 9;33(1):R33-R36. doi: 10.1016/j.cub.2022.11.025.

Authors

Filip Van Hauwermeiren¹, Mohamed Lamkanfi²

Affiliations

¹ Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, B-2340, Belgium.
² Laboratory of Medical Immunology, Department of Internal Medicine and Paediatrics, Ghent University, Ghent, B-9000, Belgium. Electronic address: [email protected].

PMID: 36626862
DOI: 10.1016/j.cub.2022.11.025

Abstract

A new study reveals how Mycobacterium tuberculosis evades anti-bacterial immunity by modifying the plasma membrane phospholipid composition of infected macrophages, thereby blocking the host's pyroptosis response and supporting chronic infection.

Publication types

Comment

MeSH terms

Humans
Inflammasomes / metabolism
Macrophages / metabolism
Mycobacterium tuberculosis*
Tuberculosis* / metabolism
Tuberculosis* / microbiology

Substances

Inflammasomes