Clinical parameters correlated with the psoas muscle index in Japanese individuals with type 2 diabetes mellitus

Emi Asano-Hayami; Yoshiaki Morishita; Tomohide Hayami; Yuka Shibata; Toshiki Kiyose; Sachiko Sasajima; Yusuke Hayashi; Mikio Motegi; Makoto Kato; Saeko Asano; Hiromi Nakai-Shimoda; Yuichiro Yamada; Emiri Miura-Yura; Tatsuhito Himeno; Masaki Kondo; Shin Tsunekawa; Yoshiro Kato; Jiro Nakamura; Hideki Kamiya

doi:10.1007/s13340-022-00602-0

Clinical parameters correlated with the psoas muscle index in Japanese individuals with type 2 diabetes mellitus

Diabetol Int. 2022 Sep 11;14(1):76-85. doi: 10.1007/s13340-022-00602-0. eCollection 2023 Jan.

Authors

Emi Asano-Hayami¹, Yoshiaki Morishita¹, Tomohide Hayami¹, Yuka Shibata^{1

2}, Toshiki Kiyose¹, Sachiko Sasajima¹, Yusuke Hayashi¹, Mikio Motegi¹, Makoto Kato¹, Saeko Asano¹, Hiromi Nakai-Shimoda¹, Yuichiro Yamada¹, Emiri Miura-Yura¹, Tatsuhito Himeno^{1

3}, Masaki Kondo¹, Shin Tsunekawa¹, Yoshiro Kato¹, Jiro Nakamura^{1

3}, Hideki Kamiya¹

Affiliations

¹ Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195 Japan.
² Department of Clinical Laboratory, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195 Japan.
³ Department of Innovative Diabetes Therapy, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195 Japan.

Abstract

Aims: Muscle atrophy is a diabetic complication, which results in a deterioration in glycemic control in type 2 diabetes mellitus (T2DM) individuals. The psoas muscle mass index (PMI) is a reliable indicator for estimating whole-body muscle mass. We aimed to examine the relationship between clinical parameters and the PMI to clarify the mechanism underlying muscle atrophy in diabetes.

Methods: This retrospective, cross-sectional study examined 51 patients (31 men and 20 women) with T2DM and a mean HbA1c value of 9.9 ± 1.7%. These patients were admitted to Aichi Medical University Hospital and underwent abdominal computed tomography imaging from July 2020 to April 2021. Multiple clinical parameters were assessed with the PMI.

Results: In a multiple regression analysis adjusted for age and sex, the PMI was correlated with body weight, body mass index, serum concentrations of corrected calcium, aspartate aminotransferase, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone (TSH), urinary C-peptide concentrations, the free triiodothyronine/free thyroxine (FT3/FT4) ratio, and the young adult mean score at the femur neck. Receiver operating characteristic curves were created using TSH concentrations and the FT3/FT4 ratio for diagnosing a low PMI. The area under the curve was 0.593 and 0.699, respectively. The cut-off value with maximum accuracy for TSH concentrations was 1.491 μIU/mL, sensitivity was 56.1%, and specificity was 80.0%. Corresponding values for the FT3/FT4 ratio were 1.723, 78.0, and 66.7%, respectively.

Conclusion: TSH concentrations and the FT3/FT4 ratio are correlated with the PMI, and their thresholds may help prevent muscle mass loss in Japanese individuals with T2DM.

Keywords: Muscle mass loss; Psoas muscle index; Thyroid function; Type 2 diabetes.

© The Japan Diabetes Society 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.