Prevalence and incidence of HEV among men using HIV pre-exposure prophylaxis: A sub-study of the ANRS IPERGAY trial

Marie-Laure Chaix; Nicolas Leturque; Audrey Gabassi; Isabelle Charreau; Marine Minier; Gilles Pialoux; Éric Cua; Christian Chidiac; François Raffi; Cécile Tremblay; Laurence Meyer; Jean-Michel Molina; Constance Delaugerre; ANRS IPERGAY study group

doi:10.1016/j.jcv.2023.105380

Prevalence and incidence of HEV among men using HIV pre-exposure prophylaxis: A sub-study of the ANRS IPERGAY trial

J Clin Virol. 2023 Mar:160:105380. doi: 10.1016/j.jcv.2023.105380. Epub 2023 Jan 9.

Affiliations

¹ Virologie, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France; INSERM U944, CNRS UMR 7212, Institut Universitaire d'Hématologie, Université Paris Cité, Hôpital Saint Louis, 75010 Paris, France. Electronic address: [email protected].
² INSERM SC10 US19, Villejuif, France.
³ Virologie, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France.
⁴ Maladies infectieuses, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris, France.
⁵ Maladies infectieuses, Hôpital de l'Archet, Centre Hospitalier de Nice, France.
⁶ Maladies infectieuses, Hôpital de la Croix Rousse, Centre Hospitalier et Universitaire de Lyon, France.
⁷ Department of Infectious Diseases, University Hospital of Nantes and CIC 1413, INSERM, Nantes, France.
⁸ Maladies infectieuses, Centre Hospitalier de l'Université de Montréal, Canada.
⁹ INSERM SC10 US19, Villejuif, France; Université Paris-Sud, Université Paris-Saclay, France.
¹⁰ INSERM U944, CNRS UMR 7212, Institut Universitaire d'Hématologie, Université Paris Cité, Hôpital Saint Louis, 75010 Paris, France; Maladies infectieuses, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France.
¹¹ Virologie, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France; INSERM U944, CNRS UMR 7212, Institut Universitaire d'Hématologie, Université Paris Cité, Hôpital Saint Louis, 75010 Paris, France.

PMID: 36638749
DOI: 10.1016/j.jcv.2023.105380

Abstract

Background: Men who have sex with men (MSM) have an increased risk of infection by pathogens transmitted by the oro-fecal route. Here, we investigated the seroprevalence and incidence of hepatitis E virus (HEV) infection in 416 MSM included in the ANRS IPERGAY PrEP trial.

Results: Among the 62 (14.9% (95% CI: [11.6%-18.7%]) seropositive for HEV at inclusion, the only factor associated with testing seropositive for HEV was older age. Geographical origin, use of recreational drugs, number of sexual partners, status for HAV and bacterial sexually transmitted infection (STI) at inclusion were not associated. Among the 342 HEV-seronegative patients with available samples, 9 seroconverted after a median of follow-up of 2.1 years (IQR (interquartile range): [1.6; 3.0]).

Conclusion: Overall, the HEV incidence was 1.19% per 100 person-years [95% CI: 0.54%; 2.26%]. Sexual transmission does not seem to be a major route of HEV infection in MSM, unlike HAV.

Keywords: HIV pre-exposure prophylaxis; Hepatitis E virus; Incidence; MSM; Seroprevalence.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

HIV Infections*
Hepatitis E virus*
Hepatitis E* / epidemiology
Homosexuality, Male
Humans
Incidence
Male
Pre-Exposure Prophylaxis*
Prevalence
Seroepidemiologic Studies
Sexual and Gender Minorities*